Virchows Archiv A

, Volume 395, Issue 1, pp 1–9 | Cite as

Alpha-1-antitrypsin in malakoplakia

  • Francesco Callea
  • Boudewijn Van Damme
  • Valeer J. Desmet
Original Articles


Macrophages in malakoplakia contain large amounts of immuno-reactive alpha-1-antitrypsin (AAT). The amount of AAT remains unchanged during the morphogenetic stages of the pathological process (early, granulomatous, fibrosing phases), and does not correlate with the number or the presence of Michaelis-Gutmann (M.G.) bodies.

Macrophages from other pathological processes, closely resembling malakoplakia cells but without M.G. bodies, did not contain AAT, except for a few macrophages in tuberculosis and xanthogranulomatous pyelonephritis.

Whatever the source and the pathogenic role of AAT in malakoplakia, its presence in all macrophages seems to be specific for this disease. Immuno-histochemical staining for AAT is therefore proposed as a useful test for an early and accurate differential diagnosis of malakoplakia.

Key words

Malakoplakia Macrophages Alpha-1-antitrypsin Michaelis Gutmann bodies Immunohistochemistry 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Francesco Callea
    • 1
  • Boudewijn Van Damme
    • 1
  • Valeer J. Desmet
    • 1
  1. 1.Laboratorium voor Cyto- en Histochemie, Departement Medische NavorsingKatholieke Universiteit LeuvenLeuvenBelgium

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