European Journal of Pediatrics

, Volume 140, Issue 3, pp 278–281 | Cite as

Hypochondrogenesis; an additional case

  • G. Hendrickx
  • F. Hoefsloot
  • P. Kramer
  • U. Van Haelst
Case Report

Abstract

In a case of hypochondrogenesis, abnormal fat deposits were found in the chondrocytes, by anatomopathological and by ultrastructural examination. In the cultured fibroblast we were unable to demonstrate abnormal lipid loading. Our case could be isolated from other types of lethal congenital chondrodysplasias —especially the lethal type of spondyloepiphyseal dysplasia congenita—by microscopic and ultrastructural investigations.

Key words

Achondrogenesis type II Chondrodysplasia Fibroblasts in vitro Hypochondrogenesis Spondyloepiphyseal dysplasia congenita 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • G. Hendrickx
    • 1
  • F. Hoefsloot
    • 2
  • P. Kramer
    • 3
  • U. Van Haelst
    • 4
  1. 1.Department of PaediatricsUniversity Children's Hospital Het Wilhelmina Kinderziekenhuis UtrechtThe Netherlands
  2. 2.Department of Pathology, Diaconessenhuis EindhovenUniversity Children's Hospital, Het Wilhelmina Kinderziekenhuis UtrechtThe Netherlands
  3. 3.Department of RadiologyUniversity Children's Hospital, Het Wilhelmina Kinderziekenhuis UtrechtThe Netherlands
  4. 4.Department of PathologyUniversity of NymegenThe Netherlands

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