Mycopathologia

, Volume 72, Issue 1, pp 35–45 | Cite as

Ketoconazole in Paracoccidioidomycosis: Efficacy of prolonged oral therapy

  • A. Restrepo
  • D. A. Stevens
  • E. Leiderman
  • J. Fuentes
  • A. Arana
  • R. Angel
  • G. Mejía
  • I. Gómez
Article

Summary

Ketoconazole, a new oral imidazole derivative, was employed for the treatment of five patients with paracoccidioidomycosis. The response was excellent, with objective clinical improvement and healing of both mucocutaneous and pulmonary lesions. Mycological and serological tests, as well as delayed hypersensitivity, were assessed and found to correlate with clinical improvement. Therapy was conducted for 12 months with a dose of 200 mg day in 2 patients; in the remainder the dose was reduced (100 mg day) after the first 6 months and maintained as such for an equal period. No side-effects or toxicity were noted despite prolonged treatment. The advantages of the new therapeutic approach are discussed.

Keywords

Toxicity Imidazole Therapeutic Approach Clinical Improvement Ketoconazole 

Sumario

Un nuevo derivado del imidazole para uso oral, ketoconazole, fué empleado en el tratamiento de 5 pacientes con paracoccidioidomicosis. Se condujo la terapia por un año, con base a la administración de una pastilla (200 mg) por día en 2 pacientes; en los 3 restantes, esta dosis fué reducida a la mitad y mantenida en tal nivel por otros 6 meses. La respuesta fué excelente con mejoría clínica objetiva y cicatrización de las lesiones tegumentarias y pulmonares. Los estudios micológicos y serológicos, a la par que la sensibilidad cutanea, llevados a cabo durante el curso del tratamiento indicaron también mejoría. No se anotó ninguna toxicidad para la droga ni los pacientes experimentaron efectos secundarios. Las ventajas de esta nueva clase de terapia son discutidas en el texto.

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Copyright information

© Dr. W. Junk B.V. Publishers 1980

Authors and Affiliations

  • A. Restrepo
    • 1
  • D. A. Stevens
    • 2
  • E. Leiderman
    • 3
  • J. Fuentes
    • 4
  • A. Arana
    • 4
  • R. Angel
    • 3
  • G. Mejía
    • 1
  • I. Gómez
    • 1
  1. 1.Corporacion de Investigaciones Biológicas (CIB) and Hospital Pablo Tobón UribeMedellínColombia
  2. 2.Division of Infectious Diseases, Santa Clara Valley Medical CenterStanford UniversitySan JoséUSA
  3. 3.Departamento de Medicina InternaInstituto de los Seguros SocialesMedellínColombia
  4. 4.Hospital La MaríaMedellínColombia

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