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European Journal of Pediatrics

, Volume 136, Issue 3, pp 245–248 | Cite as

The Wiedemann-Rautenstrauch or neonatal progeroid syndrome

Report of a patient with consanguineous parents
  • Eric A. Devos
  • Jules G. Leroy
  • Jean-Pierre Frijns
  • Herman Van den Berghe
Original Investigations

Abstract

A 4-year-old girl is reported with a neonatally apparent progeroid syndrome. Parental consanguinity indicates autosomal recessive inheritance. Psychomotor development and physical growth are severely deficient. Mainly characterized by congenital absence of subcutaneous fat tissue, this child is very similar to four patients reported earlier and recognized as representing a newly delineated clinical entity, called here the Wiedemann-Rautenstrauch or neonatal progeroid syndrome.

Key words

Neonatal Progeroid Absent subcutaneous fat Autosomal recessive Hutchinson-Gilford progeria Hallermann-Streiff syndrome Congenital lipoatrophic diabetes 

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References

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    Wiedemann H-R (1979) An unidentified neonatal progeroid syndrome: follow-up report. Eur J Pediatr 130:65–70Google Scholar
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    Rautenstrauch F, Snigula F, Krieg T, Gay S, Müller PK (1977) Progeria: a cell culture study and clinical report of familial incidence. Eur J Pediatr 124:101–111Google Scholar
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    Leroy JG, Devos EA (1978) Severe congenital hypotrophy: a syndrome with autosomal recessive inheritance. Birth Defects, OAS, 14 (6 B), 374–375Google Scholar
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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Eric A. Devos
    • 1
  • Jules G. Leroy
    • 2
  • Jean-Pierre Frijns
    • 3
  • Herman Van den Berghe
    • 3
  1. 1.Division of Pediatrics“H. Hart”-HospitaalRoeselareBelgium
  2. 2.Division of Medical GeneticsAntwerp University Medical SchoolWilrijkBelgium
  3. 3.Division of Human Genetics, Department of Human BiologyCatholic University of LouvainLeuvenBelgium

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