Advertisement

Psychopharmacology

, Volume 99, Issue 2, pp 287–288 | Cite as

Genetic differences in a tail suspension test for evaluating antidepressant activity

  • Ramon Trullas
  • Barrington Jackson
  • Phil Skolnick
Original Investigations

Abstract

Tail suspension-induced immobility in rodents is specifically antagonized by antidepressants, and has been proposed as an animal model of depression. Marked differences in tail suspension-induced immobility were observed among nine inbred mouse strains, ranging from 1±0.3 to 96±8-s in a 300-s test period. Moreover, these nine strains could be ranked in four distinct groups based on their immobilities, in which Balb/cJ and DBA/2J mice displayed the highest and the lowest immobility times, respectively. While significant differences in open field activity were also observed among strains, these differences were unrelated to their immobility times in the tail suspension test. These findings strongly suggest that performance in this proposed animal model of depression is under specific genetic control, and may provide a useful tool to study neurochemical and neuroendocrine correlates of depression and antidepressant action.

Key words

Inbred mouse strains Animal models Open field activity Antidepressants Affective disorders 

References

  1. Hodgkinson S, Sherrington R, Gurling H, Marchbanks R, Reeders S, Mallet J, McInnis M, Petursson H, Brynjolfsson J (1987) Molecular genetic evidence for heterogeneity in manic depression. Nature 325:805–808Google Scholar
  2. Nurnberger JI, Goldin LR, Gershon ES (1986) Genetics of psychiatric disorders. In: Winokur G, Clayton P (eds) The medical basis of psychiatry. Saunders, Philadelphia, pp 486–521Google Scholar
  3. Porsolt RD (1981) Behavioral despair. In: Enna SJ, Malick JB, Richelson E (eds) Antidepressants: neurochemical, behavioral and clinical perspectives. Raven Press, New York, pp 121–139Google Scholar
  4. Porsolt RD, Bertin A, Jalfre M (1978) “Behavioural Despair” in rats and mice: strain differences and the effects of imipramine. Eur J Pharmacol 51:291–294Google Scholar
  5. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367–370Google Scholar
  6. Thierry B, Steru L, Chermat R, Simon P (1984) Searching waiting strategy: a candidate for an evolutionary model of depression? Behav Neur Biol 41:180–189Google Scholar
  7. van der Heyden J, Molewijk E, Olivier B (1987) Strain differences in response to drugs in the tail suspension test for antidepressant activity. Psychopharmacology 92:127–130Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Ramon Trullas
    • 1
  • Barrington Jackson
    • 1
  • Phil Skolnick
    • 1
  1. 1.Laboratory of Neuroscience, NIDDKNational Institutes of HealthBethesdaUSA

Personalised recommendations