Abstract
The addition of lithium to the tricyclic antidepressant medication of 11 depressed patients resulted in an increase in the prolactin response to l-tryptophan after both 4 days and 4 weeks of lithium treatment. There was also a significant fall in Hamilton Depression scores. The results suggest that lithium and tricyclic antidepressants may act synergistically to enhance certain aspects of brain 5-HT function in depressed patients.
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Anderson IM, Cowen PJ (1986) Clomipramine enhances prolactin and growth hormone responses to l-tryptophan. Psychopharmacology 89:131–133
Blier P, de Montigny C (1985) Short term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. Eur J Pharmacol 113:69–77
Charig EM, Anderson IM, Robinson JM, Nutt DJ, Cowen PJ (1986) l-tryptophan and prolactin release: evidence of interaction between 5-HT1 and 5-HT2 receptors. Hum Psychopharmacol 1:93–97
Charney DS, Heninger GR, Sternberg DE (1984) Serotonin function and mechanism of action of antidepressant treatment: effect of amitriptyline and desipramine. Arch Gen Psychiatry 41:359–365
Cowen PJ (1987) Psychotropic drugs and human 5-HT neuroendocrinology. TIPS 8:105–108
Cowen PJ (1988) Prolactin responses to tryptophan during mianserin treatment. Am J Psychiatry 145:740–741
Glue PW, Cowen PJ, Nutt DJ, Kolakowska T, Grahame-Smith DG (1986) The effect of lithium on 5-HT-mediated neuroendocrine responses and platelet 5-HT receptors. Psychopharmacology 90:398–402
Goodwin GM, De Souza RJ, Wood AJ, Green AR (1986) The enhancement by lithium of the 5-HT1A-mediated serotonin syndrome produced by 8-OH-DPAT in the rat: evidence for a post-synaptic mechanism. Psychopharmacology 90:488–493
Heninger GR, Charney DS, Sternberg DE (1983) Lithium carbonate augmentation of antidepressant treatment. Arch Gen Psychiatry 40:1327–1334
Joffe RT, Post RM, Ballenger JC, Rebar R, Gold PW (1986) The effect of lithium on neuroendocrine function in affectively ill patients. Acta Psychiatr Scand 73:524–528
Lal S, Nair NP, Guyda H (1978) Effect of lithium on hypothalamic pituitary dopaminergic function. Acta Psychiatr Scand 57:91–96
McCance SL, Cowen PJ, Waller H, Grahame-Smith DG (1987) The effect of metergoline on endocrine responses to l-tryptophan. J Psychopharmacol 2:90–94
de Montigny C, Aghajanian GK (1978) Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurones to serotonin. Science 202:1303–1306
de Montigny C, Cournoyer G, Morissette R, Langlois R, Caillé G (1983) Lithium carbonate addition in tricyclic antidepressant-resistant unipolar depression. Arch Gen Psychiatry 40:1327–1334
Price LH, Charney DS, Heninger GR (1986) Variability of response to lithium augmentation in refractory depression. Am J Psychiatry 143:1387–1392
Swann AC, Heninger GR, Roth RH, Maas JW (1981) Differential effects of short- and long-term lithium on tryptophan uptake and serotonergic function in cat brain. Life Sci 28:347–354
Treiser SL, Cascio CS, O'Donohue TL, Kellar K (1981) Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Science 213:1529–1531
Van Praag HM, Lemus C, Kahn R (1986) The pitfalls of serotonin precursors as challengers in hormonal probes of central serotonin activity. Psychopharmacol Bull 22:565–570
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Cowen, P.J., McCance, S.L., Cohen, P.R. et al. Lithium increases 5-HT-mediated neuroendocrine responses in tricyclic resistant depression. Psychopharmacology 99, 230–232 (1989). https://doi.org/10.1007/BF00442813
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DOI: https://doi.org/10.1007/BF00442813