Mycopathologia

, Volume 110, Issue 1, pp 31–35 | Cite as

Conversion of versiconal acetate to versiconal and versicolorin C in extracts from Aspergillus parasiticus

  • John A. Anderson
  • Chang Ho Chung
Article

Abstract

The primary product of hydrolysis of versiconal acetate catalyzed by porcine liver esterase and the 35–70% ammonium sulfate fraction from a soluble extract from mycelia of Aspergillus parasiticus was versiconal. Versiconal was stable at neutral pH for several hours and was rapidly converted to versi-colorin C by treatment with 0.4 M HCl. The addition of NADPH to the 35–70% ammonium sulfate fraction resulted in conversion of versiconal acetate to both versiconal and versicolorin C. The conversion of versiconal acetate to versicolorin C in the cell-free system is proposed to involve an esterase and an NADPH-dependent cyclase.

Key words

versiconal aflatoxin Aspergillus versicolorin C 

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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • John A. Anderson
    • 1
  • Chang Ho Chung
    • 2
  1. 1.Department of Chemistry and BiochemistryTexas Tech UniversityLubbockUSA
  2. 2.Department of BiochemistryMichigan State UniversityEast LansingUSA

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