, Volume 110, Issue 1, pp 11–18 | Cite as

Subchronic oral toxicity of cyclopiazonic acid (CPA) in male Sprague-Dawley rats

  • Kenneth A. Voss
  • William P. Norred
  • Dorothy M. Hinton
  • Richard J. Cole
  • Joe W. Dorner


The mycotoxin cyclopiazonic acid (CPA) is a potential contaminant of processed foods, grain and poultry. Twelve male Sprague-Dawley rats were given oral doses of 0, 0.2, 0.6, 2.0 or 4.0 mg CPA/kg body weight/day for 13 consecutive weeks to study its potential subchronic toxicity. No dose-related mortality or morbidity occurred. General appearance, behavior, body weight gain and food consumption of all groups were similar. CPA had no definite adverse hematologic or serum chemistry effects, although serum creatinine concentrations of rats given 2.0 and 4.0 mg CPA/kg BW were increased after seven and 13 weeks. Mild to focally moderate acute inflammation of the lamina propria and submucosa of the gastric epithelium was found in animals given ≥ 0.6 mg CPA/kg BW. No other dose-related microscopic lesions were found. Ultrastructural examination of the livers revealed subtle disruption of the cisternal pattern of the endoplasmic reticulum with ribosomal detachment in animals receiving 4.0, but not 2.0, mg CPA/kg BW. These data suggest that the toxic effects in rats of repeated, daily oral exposure to CPA may be less than previously reported. The possible relationship between toxicity and CPA epimerization is considered.

Key words

oral toxicity cyclopiazonic acid 


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Kenneth A. Voss
    • 1
  • William P. Norred
    • 1
  • Dorothy M. Hinton
    • 1
  • Richard J. Cole
    • 2
  • Joe W. Dorner
    • 2
  1. 1.Toxicology and Mycotoxin Research Unit, U.S. Department of Agriculture, Agricultural Research ServiceR.B. Russell Agricultural Research CenterAthensUSA
  2. 2.U.S. Department of Agriculture, Agricultural Research ServiceNational Peanut Research LaboratoryDawsonUSA

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