European Journal of Pediatrics

, Volume 147, Issue 3, pp 315–316 | Cite as

Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus

  • O. Pryds
  • G. Greisen
  • K. H. Johansen
Short Communications


Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%–40%), the mean fall was 24% (P<0.005). Though none of the infants showed signs of impaired cerebral function during or following the injections, the results do not indicate whether or not the use of indomethacin is a potential hazard.

Key words

Cerebral blood flow Indomethacin Patent ductus arteriosus Premature infants 



patent ductus arteriosus


cerebral blood flow


arterial carbon dioxide tension


mean arterial blood pressure


  1. 1.
    Cowan F (1986) Indomethacin, patent ductus arteriosus, and cerebral blood flow. J Pediatr 109:341–344Google Scholar
  2. 2.
    Duc G, Jaggi JL, Lipp AE (1987) Effects of respiratory intervention on cerebral blood flow (CBF) in preterm infants. International neonatal intensive care collegium, SassaryGoogle Scholar
  3. 3.
    Greisen G (1986) Cerebral blood flow in preterm infants during the first week of life. Acta Pædiatr Scand 75:43–51Google Scholar
  4. 4.
    McCulloch J, Kelly PAT, Grome JJ, Pickard JD (1982) Local cerebral circulatory and metabolic effects of indomethacin. Am J Physiol 12:416–423Google Scholar
  5. 5.
    Obrist WD, Thompsen HK, Wang HS, Wilkinson WE (1975) Regional cerebral blood flow estimated by 133-Xenon inhalation. Stroke 6:245–256Google Scholar
  6. 6.
    Perlman JM, Hill A, Volpe JJ (1981) The effect of patent ductus arteriosus on flow velocity in the anterior cerebral arteries: ductul steal in the premature newborn infant. J Pediatr 99:767–777Google Scholar
  7. 7.
    Sakabe T, Siesjø BK (1979) The effect of indomethacin on the blood flow-metabolism couple in the brain under normal, hypercapnic and hypoxic conditions. Acta Physiol Scand 107:283–284Google Scholar
  8. 8.
    Wennmalm Å (1982) Participation of prostaglandins in the regulation of peripheral vascular resistance. In: Oates JA (ed) Prostaglandins and the cardiovascular system. Raven Press, New York, pp 303–331Google Scholar
  9. 9.
    Wennmalm Å, Eriksson S, Wahren J (1981) Effect of indomethacin on basal and carbon dioxide stimulated cerebral blood flow in man. Clin Physiol 1:227–234Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • O. Pryds
    • 1
  • G. Greisen
    • 1
  • K. H. Johansen
    • 1
  1. 1.Department of NeonatologyState University Hospital of Copenhagen, RigshospitaletCopenhagen ØDenmark

Personalised recommendations