Abstract
Long-term selenium status in children from the North-East of Scotland was estimated using whole blood selenium content (BSe) and glutathione peroxidase activity (BGSH-Px). BSe was significantly lower than the reference range in children with cystic fibrosis, coeliac disease and in older patients with phenylketonuria. Whereas BGSH-Px of all the children with coeliac disease and those with cystic fibrosis aged over 6 years matched the reference range, it was reduced in younger patients with cystic fibrosis and in children with dietetically treated phenylketonuria. No child had clinical features of selenium deficiency. BSe in treated epileptics and asthmatics conformed to the reference range, but BGSH-Px in both groups was increased significantly; this was most evident in those receiving corticosteroid preparations.
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References
Arthur JR, Price J, Mills CF (1979) Observations of the selenium status of cattle in the north-east of Scotland. Vet Rec 104:340–351
Burk RF, Pearson WN, Wood RP, Viteri F (1967) Blood-selenium levels and in vitro red blood cell uptake of 75Se in Kwashiorkor. Am J Clin Nutr 20:723–733
Castillo R, Landon C, Eckhardt K, Morris V, Levander O, Lewiston N (1981) Selenium and vitamin E status in cystic fibrosis. J Pediatr 99:583–585
Chance B, Sies H, Boveris A (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527–605
Chen X, Yang G, Chen J, Chen X, Wen Z, Ge K (1980) Studies on the relations of selenium and Keshan disease. Biol Trace Element Research 2:91–107
Collip PJ, Chen SY (1981) Cardiomyopathy and selenium deficiency in a two-year-old girl. N Engl J Med 204:1034–1035
Dyer DG, Schuett VE, Ganther HE (1978) Nutrition in transition. In: White PL, Selvey N (eds) Proceedings of the Western Hemisphere Nutrition Congress, V Monroe WI, AMA, p 417
Ganther HE, Hafeman DG, Lawerence RA, Serfass RE, Hoekstra WG (1976) Selenium and Glutathione Peroxidase in Health and Disease. In: Prasad AS and Oberleas D (eds) Trace elements in human health and disease. vol II. Academic Press, New York, pp 165–234
Heinrich HC, Gabbe EE, Bartels H (1977) Bioavailability of food iron (59Fe) Vitamin B12 (60Co) and protein-bound Selenomethionine (75Se) in pancreatic exocrine deficiency due to cystic fibrosis. Klin Wochenschr 55:595–601
Lloyd-Still JD, Ganther HE (1980) Selenium and GSH-Px levels in cystic fibrosis. Pediatrics 65:1010–1012
Lombeck I, Kasperek K, Harbisch HD, Feinendegen LE, Bremer HJ (1977) The selenium state of healthy children. 1. Serum selenium concentration at different ages. Activity of glutathione peroxidase of erythrocytes at different ages. Selenium content of food of infants. Eur J Pediatr 125:81–88
Lombeck I, Kasperek K, Harbisch HD, Becker K, Schumann E, Schroter W, Feinendegen LE, Bremer HJ (1978) The selenium state of children. 2. Selenium content of serum, whole blood, hair and the activity of erythrocyte glutathione peroxidase in dietetically treated patients with phenylketonuria and maple syrup urine disease. Eur J Pediatr 128:213–233
Lombeck I, Kasperek K, Bachmann D, Feinendegen LE, Bremer HJ (1980) Selenium requirements in patients with inborn errors of amino acid metabolism and selenium deficiency. Eur J Pediatr 134:65–68
McKenzie RL, Rea HM, Thomson CD, Robinson MF (1978) Selenium concentration and glutathione peroxidase activity in blood of New Zealand infants and children. Am J Clin Nutr 31:1413–1418
Olsen OE, Palmer IS, Cary EE (1975) Modification of the official fluorometric method for selenium in plants. J Assoc Off Anal Chem 58:117–121
Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158–169
Prohaska JR, Ganther HE (1977) Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver. Biochem Biophys Res Commun 76:437–445
Rudolph N, Wong SL (1978) Selenium and glutathione peroxidase activity in maternal and cord plasma and red cells. Pediatr Res 12:789–792
Salonen JT, Alfthan G, Huttunen JK, Pikkarainen J, Puska P (1982) Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study. Lancet ii:175–179
Thomson CD, Robinson MF (1980) Selenium in human health and disease, with emphasis on those aspects peculiar to New Zealand. Am J Clin Nutr 33:303–323
Thorn J, Robertson J, Buss DH, Bunton NG (1978) Trace nutrients: Selenium in British food. Br J Nutr 39:391–396
Van Rij AM, Thomson CD, McKenzie JM, Robinson MF (1979) Selenium deficiency in total parenteral nutrition. Am J Clin Nutr 32:2076–2085
Wallach J (1979) NIAMDD-CFF Workshop on Model Systems for the Study of Cystic Fibrosis, May 25–26 1978, Bethesda, MD
Watkinson JH (1981) Changes of blood selenium in New Zealand adults with time and importation of Australian wheat. Am J Clin Nutr 34:936–942
Willet WC, Morris JS, Pressel S, Taylor JO, Polk BF, Stampfer MJ, Rosner B, Schneider K, Hames CG (1983) Prediagnostic serum selenium and risk of cancer. Lancet ii:130–133
Editorial (1983) Selenium perspective. Lancet i:685
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Ward, K.P., Arthur, J.R., Russell, G. et al. Blood selenium content and glutathione peroxidase activity in children with cystic fibrosis, coeliac disease, asthma, and epilepsy. Eur J Pediatr 142, 21–24 (1984). https://doi.org/10.1007/BF00442584
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DOI: https://doi.org/10.1007/BF00442584