Mycopathologia

, Volume 60, Issue 1, pp 39–43 | Cite as

Histoplasmosis in purebred mice: Influence of genetic susceptibility and immune depression on treatment

  • R. Michael Patton
  • Allan R. Riggs
  • Suzanne B. Compton
  • Ernest W. Chick
Article

Abstract

These experiments demonstrate that susceptibility to Histoplasma infection of the mouse is dramatically influenced by genetic and immunologic factors, and that these factors appear to exert little influence on response to therapy. They further demonstrate that such influence may vary in different visceral organs. The explanation for these observations remains to be elucidated.

Keywords

Depression Genetic Susceptibility Histoplasmosis Visceral Organ Immunologic Factor 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adamson, D.M. & G.C. Cozad. 1969. Effect of antilymphocyte serum on animals experimentally infected with Histoplasma capsulatum or Cryptococcus neoformans. J. Bacteriol. 100: 1271–1276.Google Scholar
  2. 2.
    Baumann, D.S. & E.W. Chick. 1969. An experimental model for studying extrapulmonary dissemination of Histoplasma capsulatum in hamsters. Am. Rev. Resp. Dis. 100: 79–81.Google Scholar
  3. 3.
    Bauman, D.S. & E.W. Chick. 1973. Acute cavitary histoplasmosis in Rhesus monkeys. Influence of immunologic status. Infect. & Immun. 8: 245–248.Google Scholar
  4. 4.
    Chick, E.W. & G.D. Roberts. 1974. The varying susceptibility of different genetic strains of laboratory mice to Histoplasma capsulatum. Mycopath. Mycol. Appl. 52: 251–253.Google Scholar
  5. 5.
    Smith, C.D. & N.L. Goodman. 1975. Improved culture method for the isolation of Histoplasma capsulatum and Blastomyces dermatitidis from contaminated specimens. Am. J. Clin. Path. 63: 276–280.Google Scholar
  6. 6.
    Spencer, H.D. The Role of Delayed Hypersensitivity in Blastomycosis of Mice. Doctorate Dissertation, University of Oklahoma Graduate College, Norman, Oklahoma.Google Scholar

Copyright information

© Dr. W. Junk bv - Publishers 1976

Authors and Affiliations

  • R. Michael Patton
    • 1
  • Allan R. Riggs
    • 1
  • Suzanne B. Compton
    • 1
  • Ernest W. Chick
    • 1
  1. 1.Research Laboratory in Mycology, Veterans Administration Hospital & Division of Mycological Diseases, Department of Community Medicine, School of MedicineUniversity of KentuckyLexingtonUSA

Personalised recommendations