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European Journal of Pediatrics

, Volume 138, Issue 4, pp 301–303 | Cite as

A new genetic disorder: Autosomal-dominant multiple benign ring-shaped skin creases

  • J. Kunze
  • H. Riehm
Original Investigations

Abstract

We describe two families with autosomal-dominant transmission of benign ring-shaped skin creases: a father and his son with cleft palate and localized neuroblastoma in one family and a father and his two daughters-one with median cleft palate-in the second family, who showed circular skin creases on both arms and fingers, which almost disappeared in later life. Multiple benign deep ring-shaped skin alterations in a newborn of a third family are suggestive for a new dominant mutation. Our new observations should not be confused with amniotic ring constrictions.

Key words

Congenital ring constriction Aberrant tissue bands Amniotic band syndrome Disruption complex Autosomal-dominant multiple benign deep ring-shaped skin creases Neuroblastoma Cleft palate 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • J. Kunze
    • 1
    • 2
  • H. Riehm
    • 2
  1. 1.Institute of Human GeneticsFree University of BerlinBerlin 19
  2. 2.Department of PediatricsFree University of BerlinBerlin 19

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