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Effect of low-dose dopamine infusion on urinary prostaglandin E2 excretion in sick, preterm infants

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Abstract

In pharmacological doses dopamine (DA) will interact with several endocrine systems and both inhibit (prolactin, thyrotropin) and enhance (renin, angiotensin) hormonal release. In this study we have examined whether DA given to preterm neonates will influence prostaglandin (PG) production. The question is of importance since vasodilatator PGs play a role in postnatal adaptation. We determined the effect of low dose DA infusion on the 24 h urinary PGE2 excretion rate (an index of renal PGE2 synthesis) in preterm infants. Six preterm neonates, with a 24-h requirement of 2 μg/kg per min DA treatment for oedema, moderate oliguria, poor peripheral perfusion and/or mild systemic hypotension were studied on days 2 (Day 1), 3 (Day 2, the day of DA infusion), and 4 (Day 3, DA discontinued) of life. Six preterm infants (control group) that did not require DA infusion were also studied to monitor possible spontaneous changes in the renal PGE2 production on days 2, 3 and 4 of life. In the control group urine output (Uv) and PGE2 excretion rate remained unchanged during the study. In the study group DA administration resulted in nearly two-fold increases in both the Uv (194%) and PGE2 excretion (182%). Urinary PGE2 excretion was, however, closely related to urine flow in both the control infants (Day 1–3) and the study group infants (Day 1–2). Since increased diuresis stimulates renal PGE2 production, our data suggest that the increased PGE2 excretion on Day 2 in the study group was not due to a direct effect of DA on PGE2 synthesis. On Day 3, however, urinary PGE2 excretion in the study group decreased out of proportion to that of the Uv (-66% vs-23%), indicating that discontinuation of the drug infusion directly decreases renal PGE2 synthesis. In conclusion, the findings of the present study indicate that low dose DA does not directly trigger renal PGE2 production in the sick preterm infant.

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Abbreviations

DA:

dopamine

PG:

prostaglandin

Uv :

urine output

PGE2 excr:

PGE2 excretion rate

PGE2 conc:

PGE2 concentration

SD:

standard deviation

UNa, UK :

urinary sodium, potassium excretion

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Authors and Affiliations

  1. Department of Developmental Physiology, Karolinska Institute, Stockholm, Sweden

    I. Seri & A. Aperia

  2. The First Department of Obstetrics and Gynecology, Neonatal Intensive Centre, Budapest, Hungary

    J. Hajdu & J. Kiszel

  3. The First Department of Paediatrics, Semmelweis University Medical School, Budapest, Hungary

    T. Tulassay

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  1. I. Seri
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  2. J. Hajdu
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  3. J. Kiszel
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  4. T. Tulassay
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  5. A. Aperia
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Seri, I., Hajdu, J., Kiszel, J. et al. Effect of low-dose dopamine infusion on urinary prostaglandin E2 excretion in sick, preterm infants. Eur J Pediatr 147, 616–620 (1988). https://doi.org/10.1007/BF00442476

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  • DOI: https://doi.org/10.1007/BF00442476

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