European Journal of Pediatrics

, Volume 132, Issue 3, pp 161–168 | Cite as

Metabolic acidosis in patients receiving anticonvulsants

  • Bunsaku Nagai
  • Ichiro Matsuda
  • Takahito Kondo
  • Naoyuki Taniguchi
  • Shinichiro Arashima
  • Takashi Mitsuyama
  • Yogo Oka
  • Masakatsu Honma
Original Investigations

Abstract

Blood pH, bicarbonate, PCO2, serum calcium, alkaline phosphatase and red cell carbonic anhydrase were measured in 37 selected patients receiving anticonvulsants. Patients with metabolic acidosis showed a high incidence of hypocalcemia with increased alkaline phosphatase and a significant reduction of carbonic anhydrase-B activity. High iPTH levels were found in 13 patients, but this was not correlated with acid-base balance status. Anticonvulsant drugs seemed to inactive carbonic anhydrase-B activity. Metabolic acidosis might be one of the factors causing a disturbance of calcium metabolism in these patients.

Key words

Anticonvulsants Metabolic acidosis Hypocalcemia Carbonic anhydrase 

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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • Bunsaku Nagai
    • 1
    • 2
    • 3
  • Ichiro Matsuda
    • 1
    • 2
    • 3
  • Takahito Kondo
    • 1
    • 2
    • 3
  • Naoyuki Taniguchi
    • 1
    • 2
    • 3
  • Shinichiro Arashima
    • 1
    • 2
    • 3
  • Takashi Mitsuyama
    • 1
    • 2
    • 3
  • Yogo Oka
    • 1
    • 2
    • 3
  • Masakatsu Honma
    • 1
    • 2
    • 3
  1. 1.Department of Pediatrics and Department of MedicineHokkaido University School of MedicineHokkaidoJapan
  2. 2.Department of Environmental MedicineHokkaido University, Graduated School of Environmental ScienceHokkaidoJapan
  3. 3.Department of PediatricsKumamoto University, Medical SchoolKumamotoJapan

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