European Journal of Pediatrics

, Volume 134, Issue 1, pp 35–38 | Cite as

Breast milk jaundice; the role of lipoprotein lipase and the free fatty acids

  • A. Constantopoulos
  • J. Messaritakis
  • N. Matsaniotis
Original Investigations


Lipoprotein lipase activity and free fatty acid concentrations were measured in samples of milk collected from mothers of infants without and with prolonged neonatal jaundice. The lipoprotein lipase and free fatty acid values in the milk from mothers of infants without jaundice were found to increase with the duration of breast-feeding until the 12th postpartum day, and then to fall to the original levels. In the group of mothers with jaundiced infants both lipoprotein lipase and free fatty acid values were found within normal limits when measured between 15th and 37th days post-partum.

These findings indicate that increased values of lipoprotein lipase and free fatty acids in the milk are not responsible for the development of breast-milk jaundice.

Key words

Lipoprotein lipase activity Breast-milk jaundice Free fatty acids Prolonged neonatal jaundice 


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  1. 1.
    Adlard, B. P. F., Lathe, G. H.: Breast milk jaundice: effect of 3-alpha-20-beta-pregnanediol on bilirubin conjugation by human liver. Arch. Dis. Childhood 45, 186–190 (1970)Google Scholar
  2. 2.
    Arias, I. M., Gartner, L. M., Seifter, S., Furman, M.: Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid pregnane-3-alpha-20-beta-diol, in maternal milk that inhibits glucuronide formation in vitro. J. Clin. Invest. 43, 2037–2046 (1964)Google Scholar
  3. 3.
    Bevan, B. R., Holton, J. B.: Inhibition of bilirubin conjugation in rat liver slices by free fatty acids, with relevance to the problem of breast milk jaundice. Clin. Chim. Acta 14, 101–104 (1972)Google Scholar
  4. 4.
    Cole, A. P., Hargreaves, T.: Conjugation inhibitors and early neonatal hyperbilirubinemia. Arch. Dis. Childhood 47, 415–419 (1972)Google Scholar
  5. 5.
    Duncombe, W. G.: The colorimetric micro-determination of non-esterified fatty acids in plasma. Clin. Chim. Acta 9, 122–125 (1964)Google Scholar
  6. 6.
    Hargreaves, T.: Effect of fatty acids on bilirubin conjugation. Arch. Dis. Childhood 48, 446–450 (1973)Google Scholar
  7. 7.
    Luzeau, R., Levillain, P., Odievre, M., Lemonnier, A.: Dépistage des laits maternels inhibiteurs de la glucuroconjugaison de la bilirubine par une réaction colorée. Arch. Fr. Pediatr. 30, 573–578 (1973)Google Scholar
  8. 8.
    Luzeau, R., Odievre, M., Levillain, P., Lemonnier, A.: Activité de la lipoproteine lipase dans les laits de femme inhibiteurs in vitro de la conjugaison de la bilirubine. Clin. Chim. Acta 59, 133–137 (1975)Google Scholar
  9. 9.
    Newman, A. J., Gross, S.: Hyperbilirubinemia in breast-fed infants. Pediatrics 32, 995–1001 (1963)Google Scholar
  10. 10.
    Odievre, M., Luzeau, R.: Lipolytic activity in milk from mothers of unjaundiced infants. Acta Paediatr. Scand. 67, 49–52 (1978)Google Scholar
  11. 11.
    Ramos, A., Silverberg, M., Stern, L.: Pregnanediols and neonatal hyperbilirubinemia. Amer. J. Dis. Children 111, 353–356 (1966)Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • A. Constantopoulos
    • 1
  • J. Messaritakis
    • 1
  • N. Matsaniotis
    • 1
  1. 1.The 1st Department of PediatricsAthens UniversityAthensGreece

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