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European Journal of Pediatrics

, Volume 129, Issue 2, pp 99–101 | Cite as

Lymph node excision as a simple diagnostic acid in rare lipidoses

  • Hildegard Debuch
  • H. -R. Wiedemann
Original Investigation

Abstract

Autopsy material from a case of Niemann-Pick disease was subjected to lipid analysis. Among the six tissues investigated, lymph nodes exhibited the greatest storage of several lipids. Since lymph nodes are relatively easy to obtain by biopsy, they may be utilized for chemical diagnosis of this type of lipidosis.

Key words

Lipidoses Niemann-Pick disease 

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References

  1. 1.
    Kannan, R., Tjiong, H. B., Debuch, H., Wiedemann, H.-R.: Unusual glycolipids in brain cortex of a visceral lipidosis (Niemann-Pick disease?). Hoppe-Seyler's Z. physiol. Chem. 355, 551–556 (1974)Google Scholar
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    Kerényi, T., Rohmányi, H., Póder, G.: Lymphknotenultrastruktur bei Niemann-Pick'scher Krankheit. Acta Morph. Acad. Sci. Hung. 19 (4), 417–432 (1971)Google Scholar
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    Tjiong, H. B., Seng, P. N., Debuch, H., Wiedemann, H.-R.: Brain lipids of a case of juvenile Niemann-Pick disease. J. Neurochem. 21, 1475–1485 (1973)Google Scholar
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    Wiedemann, H.-R., Debuch, H., Lennert, K., Caesar, R., Blümcke, S., Harms, D., Tolksdorf, M., Seng, P. N., Korenke, H.-D., Gerken, H., Freitag, F., Dörner, Kl.: Über eine infantil-juvenile, subchronisch verlaufende, den Sphingomyelinosen (Niemann-Pick) anzureihende Form der Lipidosen — eine neuer Typ? Z. Kinderheilk. 112, 187–225 (1972)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Hildegard Debuch
    • 1
  • H. -R. Wiedemann
    • 2
  1. 1.Department of BiochemistryUniversity of CologneCologneGermany
  2. 2.Department of PediatricsUniversity of KielKielGermany

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