Abstract
A five-year-old boy is described, who at 3 months of age presented with severe respiratory tract infections and later om developed signs of bronchial asthma and radiologic evidence of chronic emphysema and bronchiectasis. IgA was absent in his serum and saliva, and low serum alpha-l-antitrypsin levels with the phenotype PiMZ were found in the patient. Such dual deficiencies appear to be unusual. However, the association of IgA and alpha-l-antitrypsin deficiency should be considered in the evaluation of children with severe respiratory tract infections.
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Østergaard, P.A. Combined IgA and alpha-1-antitrypsin deficiency in a boy with severe respiratory tract infections and asthma. Eur J Pediatr 138, 83–85 (1982). https://doi.org/10.1007/BF00442338
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DOI: https://doi.org/10.1007/BF00442338