Abstract
An extensive chromosomal analysis was performed in cells of primary tumour and bone marrow metastases from an 8-month-old girl with disseminated neuroblastoma prior to therapy. A modal chromosome number of 46 was found. Consistent abnormalities in the karyotype were seen: in particular, a translocation (1;11), a deletion (2)(p21) and a chromosome 7p+. Furthermore, double minute chromosomes of two distinct sizes were found in 50%–80% of metaphases in the cell populations examined. These extra chromosomal double minutes might be the cytogenetic form of amplified cellular oncogene-DNA.
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References
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Part of F. Franke's doctoral thesis
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Franke, F., Förster, W., Rudolph, B. et al. Metastatic neuroblastoma in an infant: Translocation (1;11), deletion (2) and double minute chromosomes. Eur J Pediatr 143, 305–308 (1985). https://doi.org/10.1007/BF00442308
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DOI: https://doi.org/10.1007/BF00442308