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Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments

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Abstract

Administration of the serotonin agonist m-chlorophenylpiperazine to rats produced a dose-related hyperthermia. Pretreatment with the serotonin receptor antagonist metergoline totally abolished this response, whereas similar treatment with haloperidol, phenoxybenzamine, naloxone, clonidine, pindolol, propranolol, methiotepin, and ritanserin was ineffective. In studies investigating the modification of the response by antidepressant treatments both acute (3 day) and chronic (22 day) administration of the MAO inhibitor clorgyline, as well as the tricyclics clomipramine and imipramine, attenuated the hyperthermic response to m-CPP. These findings are discussed with regard to the specificity of m-CPP-induced hyperthermia and its subsequent modification by antidepressant treatments, in order to evaluate this model's use as a probe for assessment of the serotonergic system.

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Authors and Affiliations

  1. Laboratory of Clinical Science, National Institute of Mental Health, N.I.H. Clinical Center, Building 10, Room 3D41, 20892, Bethesda, MD, USA

    K. M. Wozniak, C. S. Aulakh, J. L. Hill & D. L. Murphy

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  1. K. M. Wozniak
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  2. C. S. Aulakh
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  3. J. L. Hill
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  4. D. L. Murphy
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Wozniak, K.M., Aulakh, C.S., Hill, J.L. et al. Hyperthermia induced by m-CPP in the rat and its modification by antidepressant treatments. Psychopharmacology 97, 269–274 (1989). https://doi.org/10.1007/BF00442262

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  • DOI: https://doi.org/10.1007/BF00442262

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