European Journal of Pediatrics

, Volume 147, Issue 2, pp 197–198 | Cite as

Low serum C4 concentrations in type-1 diabetes mellitus

  • F. Chiarelli
  • A. Verrotti
  • G. La Penna
  • G. Morgese
Short Communications


Serum levels of complement factors C3 and C4 were investigated in 64 insulin-dependent diabetic children and 52 healthy controls. The mean value of C4 was significantly lower in diabetic than in control subjects (27.99±8.01 vs 32.03±8.91 mg/dl; P<0.01). Sixteen out of 64 children had serum C4 levels below the normal range; 6 out of these 11 patients had microalbuminuria. This study demonstrates low serum levels of C4 in insulin-dependent diabetes; this reduction is not related to the duration nor to the degree of metabolic control. There is a high prevalence of microalbuminuria in patients with a low C4 concentration.

Key words

Insulin-dependent diabetes mellitus Complement Diabetic nephropathy 



albumin excretion rate


edetic acid


high performance liquid chromatography


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. Chiarelli
    • 1
  • A. Verrotti
    • 1
  • G. La Penna
    • 1
  • G. Morgese
    • 1
  1. 1.Clinica PediatricaOspedale PediatricoChietiItaly

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