Abstract
On electrophoresis, parotid saliva always exhibits a basic pattern of 6 isoamylases. Additional faster migrating isoamylases occur in varying numbers. These “fast isoamylases” are generated, at least in part, by deamidation. Compared with juvenile and adult controls, a significantly greater number of “fast isoamylases” was found in the parotid saliva of children with cystic fibrosis and their healthy heterozygous parents. A shift in the equilibrium between amidation and deamidation is discussed in terms of its possible connection with the metabolic defect responsible for cystic fibrosis.
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This paper is part of the M.D. thesis submitted by H. Lubahn to the Medical Faculty of the University of Göttingen (1977)
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Doering, K.M., Arglebe, C., Lubahn, H. et al. “Fast isoamylases” in the parotid saliva of children with cystic fibrosis and heterozygous carriers. Eur J Pediatr 126, 185–188 (1977). https://doi.org/10.1007/BF00442200
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DOI: https://doi.org/10.1007/BF00442200