European Journal of Pediatrics

, Volume 139, Issue 1, pp 48–51 | Cite as

Aseptic osteonecrosis in children treated for acute lymphoblastic leukemia and aplastic anemia

  • G. Prindull
  • W. Weigel
  • E. Jentsch
  • A. Enderle
  • H. G. Willert
Original Investigations


We report six children, five with acute leukemia and one with aplastic anemia, who during chemotherapy have developed severe aseptic bone necrosis. Although there is no definite proof, our data are highly suggestive of incriminating corticosteroid therapy in large cumulative doses as the main pathogenetic factor.

Key words

Aseptic bone necrosis Corticosteroids Leukemia Aplastic anemia 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. Prindull
    • 1
  • W. Weigel
    • 1
  • E. Jentsch
    • 1
  • A. Enderle
    • 2
  • H. G. Willert
    • 2
  1. 1.Department of PediatricsUniversity of GöttingenGermany
  2. 2.Department of OrthopedicsUniversity of GöttingenGermany

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