Abstract
We report six children, five with acute leukemia and one with aplastic anemia, who during chemotherapy have developed severe aseptic bone necrosis. Although there is no definite proof, our data are highly suggestive of incriminating corticosteroid therapy in large cumulative doses as the main pathogenetic factor.
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Prindull, G., Weigel, W., Jentsch, E. et al. Aseptic osteonecrosis in children treated for acute lymphoblastic leukemia and aplastic anemia. Eur J Pediatr 139, 48–51 (1982). https://doi.org/10.1007/BF00442079
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DOI: https://doi.org/10.1007/BF00442079