European Journal of Pediatrics

, Volume 147, Issue 5, pp 485–489 | Cite as

Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases

  • K. Akimoto
  • A. Miyata
  • K. Kangawa
  • H. Matsuo
  • Y. Koga
  • Y. Matsuoka
  • K. Hayakawa
Original Investigations


To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P<0.001), mean pulmonary arterial pressure (r=0.74, P<0.001) and right atrial pressure (r=0.53, P<0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.

Key words

Atrial natriuretic polypeptide Cardiac disease 



atrial natriuretic polypeptide


immunoreactive ANP


alpha human ANP


ventricular septal defect


atrial septal defect


patent ductus arteriosus


tetralogy of Fallot


double outlet right ventricle


total anomalous pulmonary venous drainage


complete endocardial cushion defect


tricuspid atresia


mean right atrial pressure


mean pulmonary arterial pressure


pulmonary-to-systemic blood flow ratio


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Akimoto
    • 1
  • A. Miyata
    • 2
  • K. Kangawa
    • 2
  • H. Matsuo
    • 2
  • Y. Koga
    • 3
  • Y. Matsuoka
    • 1
  • K. Hayakawa
    • 1
  1. 1.Department of PaediatricsMiyazaki Medical CollegeKiyotake, MiyazakiJapan
  2. 2.Department of BiochemistryMiyazaki Medical CollegeKiyotake, MiyazakiJapan
  3. 3.Department of SurgeryMiyazaki Medical CollegeKiyotake, MiyazakiJapan

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