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European Journal of Pediatrics

, Volume 147, Issue 5, pp 485–489 | Cite as

Plasma and right auricle concentrations of atrial natriuretic polypeptide in children with cardiac diseases

  • K. Akimoto
  • A. Miyata
  • K. Kangawa
  • H. Matsuo
  • Y. Koga
  • Y. Matsuoka
  • K. Hayakawa
Original Investigations

Abstract

To investigate the atrial natriuretic polypeptide (ANP) levels in congenital heart diseases, we measured plasma immunoreactive ANP (ir-ANP) in 29 patients with left-to-righ shunt, and right auricle ir-ANP in 25 patients who underwent operation. The levels of ir-ANP in the pulmonary artery correlated with that in the femoral vein (r=0.95, P<0.001), mean pulmonary arterial pressure (r=0.74, P<0.001) and right atrial pressure (r=0.53, P<0.01). The right auricle ir-ANP level was high in patients with heart failure combined with pressure or volume overload of the right atrium, as observed in tricuspid atresia, complete endocardial cushion defect, and total anomalous pulmonary venous drainage. These results suggest that the production of ANP in the atrium increases as a compensatory or secondary response to persistent release of ANP into the circulation in cardiac diseases.

Key words

Atrial natriuretic polypeptide Cardiac disease 

Abbreviations

ANP

atrial natriuretic polypeptide

ir-ANP

immunoreactive ANP

α-hANP

alpha human ANP

VSD

ventricular septal defect

ASD

atrial septal defect

PDA

patent ductus arteriosus

TOF

tetralogy of Fallot

DORV

double outlet right ventricle

TAPVD

total anomalous pulmonary venous drainage

cECD

complete endocardial cushion defect

TA

tricuspid atresia

MRAP

mean right atrial pressure

MPAP

mean pulmonary arterial pressure

Qp/Qs

pulmonary-to-systemic blood flow ratio

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • K. Akimoto
    • 1
  • A. Miyata
    • 2
  • K. Kangawa
    • 2
  • H. Matsuo
    • 2
  • Y. Koga
    • 3
  • Y. Matsuoka
    • 1
  • K. Hayakawa
    • 1
  1. 1.Department of PaediatricsMiyazaki Medical CollegeKiyotake, MiyazakiJapan
  2. 2.Department of BiochemistryMiyazaki Medical CollegeKiyotake, MiyazakiJapan
  3. 3.Department of SurgeryMiyazaki Medical CollegeKiyotake, MiyazakiJapan

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