European Journal of Pediatrics

, Volume 145, Issue 1–2, pp 104–108 | Cite as

Possible polyclonal B cell activation in mucocutaneous lymph node syndrome

  • F. Furukawa
  • G. Ohshio
  • Y. Hamashima
Original Investigations


Immunoserological studies on polyclonal B cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (MCLS) and in age-matched healthy individuals. The incidence of anti-mite, P. acnes (Kato) and EB virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. Serum immunoglobulin (Ig) M level and IgM-anti-dinitrophenyl (DNP) antibodies, which are considered to be parameters of polyclonal B cell activation, were determined in MCLS cases. The level of serum IgM in MCLS was significantly elevated (0.02<P<0.05). Levels of anti-DNP antibodies in seven cases of MCLS (18%) were significantly higher than those of the controls (P<0.01). Nine of the ten pair sera in MCLS showed a stage-dependent decrease in anti-DNP antibodies. These results suggest that polyclonal B cell activation occurs in MCLS.

Key words

Mucocutaneous lymph node syndrome Polyclonal B cell activation Anti-DNP antibodies 



mucocutaneous lymph node syndrome

P. acnes

Propionibacterium acnes

EB virus

Epstein-Barr virus

D. farinae

Dermatophagoides farinae


phosphatebuffered saline




room temperature


fluorescein isothiocyanate




bovine serum albumin


optical density


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • F. Furukawa
    • 1
  • G. Ohshio
    • 2
  • Y. Hamashima
    • 2
  1. 1.Department of Dermatology, Faculty of MedicineKyoto UniversityKyotoJapan
  2. 2.Department of Pathology, Faculty of MedicineKyoto UniversityKyotoJapan

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