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Possible polyclonal B cell activation in mucocutaneous lymph node syndrome

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Abstract

Immunoserological studies on polyclonal B cell activation were carried out on 39 patients with mucocutaneous lymph node syndrome (MCLS) and in age-matched healthy individuals. The incidence of anti-mite, P. acnes (Kato) and EB virus antibodies, recently proposed as aetiological agents by some investigators, was increased in the patient group. Serum immunoglobulin (Ig) M level and IgM-anti-dinitrophenyl (DNP) antibodies, which are considered to be parameters of polyclonal B cell activation, were determined in MCLS cases. The level of serum IgM in MCLS was significantly elevated (0.02<P<0.05). Levels of anti-DNP antibodies in seven cases of MCLS (18%) were significantly higher than those of the controls (P<0.01). Nine of the ten pair sera in MCLS showed a stage-dependent decrease in anti-DNP antibodies. These results suggest that polyclonal B cell activation occurs in MCLS.

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Abbreviations

MCLS:

mucocutaneous lymph node syndrome

P. acnes :

Propionibacterium acnes

EB virus:

Epstein-Barr virus

D. farinae :

Dermatophagoides farinae

PBS:

phosphatebuffered saline

Ig:

immunoglobulin

RT:

room temperature

FITC:

fluorescein isothiocyanate

DNP:

dinitrophenyl

BSA:

bovine serum albumin

OD:

optical density

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Kyoto University, Shogoin-Kawaracho, Sakyo-ku, 606, Kyoto, Japan

    F. Furukawa

  2. Department of Pathology, Faculty of Medicine, Kyoto University, Shogoin-Kawaracho, Sakyo-ku, 606, Kyoto, Japan

    G. Ohshio & Y. Hamashima

Authors
  1. F. Furukawa
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  2. G. Ohshio
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  3. Y. Hamashima
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Furukawa, F., Ohshio, G. & Hamashima, Y. Possible polyclonal B cell activation in mucocutaneous lymph node syndrome. Eur J Pediatr 145, 104–108 (1986). https://doi.org/10.1007/BF00441867

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  • DOI: https://doi.org/10.1007/BF00441867

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