European Journal of Pediatrics

, Volume 145, Issue 1–2, pp 99–103 | Cite as

Selective immunoglobulin M deficiency associated with disseminated molluscum contagiosum

  • M. Mayumi
  • K. Yamaoka
  • T. Tsutsui
  • H. Mizue
  • A. Doi
  • M. Matsuyama
  • S. Ito
  • K. Shinomiya
  • H. Mikawa
Original Investigations


A 16-year-old girl with disseminated molluscum contagiosum (MC) was found to have a very low level of serum IgM, elevated levels of IgG and IgA, and a high level of IgE. She had normal numbers of peripheral blood IgM+, IgG+ and IgA+ B-lymphocytes but their terminal differentiation into plasma cells could not be induced by pokeweed mitogen (PWM) in vitro. On the other hand, the patient's T-cells showed normal helper functions in the PWM system and normal interferon (IFN) production in vitro. However, the IgM+ B-cells can be induced to differentiate into IgM secreting cells by Epstein-Barr virus (EBV), suggesting that the genetic mechanism for synthesis of the component immunoglobulin proteins is present. T-cell functions were impaired, as shown by delayed type cutancous hypersensitivity (DTH) and mitogen response. The data suggest that the selective IgM deficiency of the patient is due mainly to defects in B-cells at the terminal differentiation stage, but immunological abnormalities are present in both B and T-cell systems. Neutrophil functions examined were normal. MC was treated by intravenous injection of IFN without any side effects; however, no clinical improvement was achieved.

Key words

Selective IgM deficiency Molluscum contagiosum Interferon 



molluscum contagiosum




delayed type cutaneous hypersensitivity


mononuclear cells


fetal calf serum


peripheral blood lymphocytes


surface Ig


pokeweed mitogen



Con A

Concanavalin A


dehydroepiandrosterone sulphate






thyloid-releasing hormone




fluorescein isothiocyanate

FL cells

human fibroblasts


Epstein-Barr virus


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • M. Mayumi
    • 1
  • K. Yamaoka
    • 2
  • T. Tsutsui
    • 2
  • H. Mizue
    • 2
  • A. Doi
    • 3
  • M. Matsuyama
    • 4
  • S. Ito
    • 1
  • K. Shinomiya
    • 1
  • H. Mikawa
    • 1
  1. 1.Department of PediatricsKyoto University HospitalKyotoJapan
  2. 2.Department of PediatricsKobe Central Municipal HospitalKobeJapan
  3. 3.Department of DermatologyKobe Central Municipal HospitalKobeJapan
  4. 4.The Public Health Research Institute of Kobe CityKobeJapan

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