European Journal of Pediatrics

, Volume 144, Issue 4, pp 383–384 | Cite as

Life-threatening intracranial hypertension in reye's syndrome treated with intravenous thiopentone

  • R. C. McWilliam
  • J. B. P. Stephenson
Original Investigations


A patient with Reye syndrome is described in whom cerebral perfusion pressure was reduced to less than 5 mm Hg with loss of EEG activity. The intravenous administration of thiopentone reduced intracranial pressure and improved cerebral perfusion pressure with restoration of EEG and full recovery.

Key words

Reye syndrome Intracranial pressure Thiopentone 



intracranial pressure




cerebral function monitor


cerebral perfusion pressure


intra-arterial pressure


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    McWilliam RC, Stephenson JBP (1984) A rapid bedside method for monitoring intracranial pressure. Lancet ii:73–75Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. C. McWilliam
    • 1
  • J. B. P. Stephenson
    • 1
  1. 1.The Intensive Therapy Department and Fraser of Allander UnitThe Royal Hospital for Sick ChildrenGlasgowUK

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