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European Journal of Pediatrics

, Volume 144, Issue 4, pp 383–384 | Cite as

Life-threatening intracranial hypertension in reye's syndrome treated with intravenous thiopentone

  • R. C. McWilliam
  • J. B. P. Stephenson
Original Investigations

Abstract

A patient with Reye syndrome is described in whom cerebral perfusion pressure was reduced to less than 5 mm Hg with loss of EEG activity. The intravenous administration of thiopentone reduced intracranial pressure and improved cerebral perfusion pressure with restoration of EEG and full recovery.

Key words

Reye syndrome Intracranial pressure Thiopentone 

Abbreviations

ICP

intracranial pressure

EEG

electroencephalograph

CFM

cerebral function monitor

CPP

cerebral perfusion pressure

IAP

intra-arterial pressure

References

  1. 1.
    DeVico DC (1983) How common is Reye's syndrome? N Engl J Med 309:179–181Google Scholar
  2. 2.
    Glasgow JFT (1984) Clinical features and prognosis of Reye's syndrome. Arch Dis Child 59:230–235Google Scholar
  3. 3.
    Hall S, Bellman M (1984) Reye's syndrome in the British Isles: first annual report of the joint British Paediatric Association and Communicable Disease Surveillance Centre surveillance scheme. Br Med J 288:548–550Google Scholar
  4. 4.
    Mayer T, Walker ML (1982) Emergeney intracranial pressure monitoring in pediatrics. Clin Pediatr 21:391–396Google Scholar
  5. 5.
    McWilliam RC, Stephenson JBP (1984) A rapid bedside method for monitoring intracranial pressure. Lancet ii:73–75Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. C. McWilliam
    • 1
  • J. B. P. Stephenson
    • 1
  1. 1.The Intensive Therapy Department and Fraser of Allander UnitThe Royal Hospital for Sick ChildrenGlasgowUK

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