Abstract
The results of clinical, biochemical and histological studies in 26 children with chronic hepatitis B are reported.
Most cases were detected when diagnostic procedures were arranged because of non specific abdominal complaints, by routine tests after acute hepatitis or multiple transfusions, and by examination of family members.
Hepatomegaly was found in half of the cases, splenomegaly in a quarter. Other clinical signs were rarely seen.
Among the biochemical findings, elevated serum transaminase activities were the most reliable indicators of chronic hepatitis. There was a significant difference of the mean transaminase activities between patients with CPH and CAH.
In 15 children CPH was diagnosed histologically. 9 children had CAH, 2 children showed signs of MinH.
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Abbreviations
- HBV:
-
hepatitis B virus
- HBsAg:
-
hepatitis B surface antigen
- anti-HBs:
-
antibody to HBsAg
- CH:
-
chronic hepatitis
- CPH:
-
chronic persistent hepatitis
- CAH:
-
chronic aggressive hepatitis
- MinH:
-
minimal hepatitis
- GOT:
-
glutamate oxaloacetate transaminase
- GPT:
-
glutamate pyruvate transaminase
- γGT:
-
gamma-glutamyltranspeptidase
- ChE:
-
cholinesterase
- GIDH:
-
glutamate dehydrogenase
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Bosch, C., Becker, M., Rotthauwe, H.W. et al. Chronic viral hepatitis B in childhood. Eur J Pediatr 135, 169–173 (1980). https://doi.org/10.1007/BF00441637
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DOI: https://doi.org/10.1007/BF00441637