Abstract
Mean corpuscular volume (MCV) and mean cellular hemoglobin (MCH) were determined by means of a Hemalog 8/90 electronic counter in 51 full-term newborn infants with α-thalassemia-2 and 15 with α-thalassemia-1, as well as in 150 normal newborn infants. The mean MCV and MCH values were 92 fl±06 and 33.26 pg±2.22 in the normal newborn infants, 82 fl±07 and 29.40 pg±2.60 in the α-thalassemia-2 subjects, and 73 fl±06 and 26.07 pg±2.05 in the α-thalassemia-1 subjects. Four of the 150 normal newborn infants had MCV's<79 fl and MCH's<29.00 pg whereas 5 of the α-thalassemic subjects had MCV's>90 fl and MCH's>32.00 pg. We conclude that MCV and MCH determinations are unreliable in the diagnosis of α-thalassemia in the neonatal period.
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References
Altay C, Ringelhann B, Yawson GI, Bruce-Tagoe AA, Konotey-Ahulu FID, James L, Gravely M, Huisman TH (1977) Hemoglobin alpha-chain deficiency in black children with variable quantities of hemoglobin Bart's at birth. Pediat Res 11:147–152
Evans DIK, Blair VM (1976) Neonatal screening for haemoglobinopathy. Results in 7691 Manchester newborns. Arch Dis Child 51:127–130
Friedman S, Atwater J, Gill FM, Schwartz E (1974) Alphathalassemia in Negro infants. Pediat Res 8:955–959
Galanello R, Cao A (1979) L'α-Thalassemia: eterogeneità, patologia molecolare, genetica, incidenza, aspetti clinici ed ematologici, fisiopatologia, associazione α-tal/varianti emoglobiniche, prevenzione e terapia. Riv It Ped 5:457–471
Martinez G, Colombo B (1976) Alpha-thalassemia in Cuba. Acta Haematol 55:36–39
Mazza U, Meloni T, David O, Pich PG, Camaschella C, Saglio G, Ciocca Vasino MA, Guerrasio A, Ricco G (1980) γ-Chain composition in five italian newborns heterozygous for Hb F Malta Gγ 117 His→Arg. Br J Haematol 44:93–99
Meloni T, Corti R, Costa S, Mele G, Franca V (in press) α-Thalassemia and hyperbilirubinemia in G-6-PD deficient newborns. Arch Dis Child
Meloni T, Pilo G, Camardella L, Cancedda F, Lania A, Pepe G, Luzzatto L (1980) Co-existence of three hemoglobins with different α-chains in two unrelated children (with family studies indicating polymorphism in the number of α-globin genes in the Sardinian population). Blood 55: 1025–1032
Pembrey ME, Weatherall DJ, Clegg JB, Bunch C, Perrine RP (1975) Haemoglobin Bart's in Saudi Arabia. Br J Haematol 29:221–234
Schmaier A, Maurer HM, Johnston C, Scott R (1973) Alpha thalassemia screening in neonates by mean corpuscular volume and mean corpuscular hemoglobin determination. J Pediat 83:794–797
Schneider RG, Haggard ME, Gustavson LP, Brimhall B, Jones RT (1974) Genetic haemoglobin abnormalities in about 9000 black and 7000 white newborns: haemoglobin F Dickinson (Aγ97 His→Arg), a new variant. Br J Haematol 28:515–524
Wasi P, Na-Nakorn S, Pootrakul S (1974) α-Thalassemias. Clin Haematol 3:383–410
Weatherall DJ, Clegg JB (1972) The Thalassemia Syndromes. Blackwell Scientific Publication. Oxford
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Meloni, T., Solinas, L., Erre, S. et al. The unreliability of mean corpuscular volume and mean cellular hemoglobin determinations in the diagnosis of α-thalassemia in newborn infants. Eur J Pediatr 135, 165–167 (1980). https://doi.org/10.1007/BF00441636
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DOI: https://doi.org/10.1007/BF00441636