European Journal of Pediatrics

, Volume 146, Issue 5, pp 531–532 | Cite as

Intravenous gamma globulin therapy for thrombocytopenic purpura associated with active varicella infection

  • T. Hara
  • Y. Mizuno
  • H. Igarashi
  • K. Ueda
Case Reports


Thrombocypenic purpura was noted in a 3-year-old Japanese girl with an active varicella infection. The administration of intravenous gamma globulin (IVG) drastically improved bleeding manifestations as well as the active varicella infection. We believe that IVG should be the first choice of therapy for thrombocytopenic purpura associated with active infections.

Key words

Varicella Thrombocytopenia Gamma globulin 



intravenous gamma globulin


idiopathic thrombocytopenic purpura


  1. 1.
    Buchanan GR (1985) Childhood acute idiopathic thrombocytopenic purpura: how many tests and how much treatment required? J Pediatr 106:928–930Google Scholar
  2. 2.
    Charkes ND (1961) Purpuric chickenpox: report of a case, review of the literature and classification by clinical features. Ann Intern Med 54:745–759Google Scholar
  3. 3.
    Chirico G, Rondini G (1985) Reply. Treatment of neonatal thrombocytopenia. J Pediatr 107:650Google Scholar
  4. 4.
    Cohn J (1976) Thrombocytopenia in childhood: an evaluation of 433 patients. Scand J Haematol 16:226–240Google Scholar
  5. 5.
    DiTuro WJ, Goldsmith PM, Frenkel LD, Jadeja NG, Dennis TR (1986) Intravenous gammaglobulin treatment of profound herpes varicella zoster associated thrombo-cytopenia. Ann Allergy 56:206, 241–243Google Scholar
  6. 6.
    Hara T, Miyazaki S, Yoshida N, Goya N (1985) High doses of gamma globulin and methylprednisolone therapy for idiopathic thrombocytopenic purpura in children. Eur J Pediatr 144:240–242Google Scholar
  7. 7.
    Hudson JB, Weinstein L, Chang T-W (1956) Thrombocytopenic purpura in measles. J Pediatr 48:48–56Google Scholar
  8. 8.
    Morse EE, Zinkham WH, Jackson DP (1966) Thrombocytopenic purpura following rubella infection in children and adults. Arch Intern Med 117:573–579Google Scholar
  9. 9.
    Wilson JJ, Neame PB, Kelton JG (1982) Infection-induced thrombocytopenia. Semin Thromb Hemost 8:217–233Google Scholar
  10. 10.
    Yeager AM, Zinkham WH (1980) Varicella associated thrombocytopenia. Clues to the etiology of childhood idiopathic thrombocytopenic purpura. Johns Hopkins Med J 146:270–274Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • T. Hara
    • 1
  • Y. Mizuno
    • 1
  • H. Igarashi
    • 1
  • K. Ueda
    • 1
  1. 1.Department of Pediatrics, Faculty of MedicineKyushu UniversityFukuoka CityJapan

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