European Journal of Pediatrics

, Volume 148, Issue 6, pp 582–583 | Cite as

Lack of relationship between low serum C4 concentrations and incipient retinopathy or nephropathy in diabetic children

  • H. Dorchy
  • J. Duchateau
Letter to the Editor


Public Health Diabetic Child 


  1. 1.
    Barnett AH, Mijovic C, Fletcher J, Chesner I, Kulkuska-Langlands BM, Holder R, Bradwell AR (1984) Low plasma C4 concentrations: association with microangiopathy in insulin-dependent diabetes. Br Med J 289:943–945Google Scholar
  2. 2.
    Charlesworth JA, Timmermans V, Golding J, Campbell LV, Peake PW, Pussel BA, Wakefield D, Howard N (1987) The complement system in type 1 (insulin-dependent) diabetes. Diabetologia 30:372–379Google Scholar
  3. 3.
    Chiarelli F, Verrotti A, La Penna G, Morgese G (1988) Low serum C4 concentrations in type-1 diabetes mellitus. Eur J Pediatr 147: 197–198Google Scholar
  4. 4.
    Cooper ME, Duff R, Buchanan R, McPherson J, Jerums G (1986) Low serum C4 concentrations and microangiopathy in type I and type II diabetes. Br Med J 292:801Google Scholar
  5. 5.
    Dorchy H, Duchateau J (1984) In vivo complement consumption in type 1 diabetic children and adolescents (abstract). Diabetes Young 11:36Google Scholar
  6. 6.
    Okada S, Sato K, Miyai Y, Masaki Y, Higuchi T, Ogino Y, Ota Z (1987) Serum C3 and C4 levels and complement-dependent antibody-mediated cytotoxic activity of islet cell surface antibody in type 1 (insulin-dependent) diabetic children. Diabetologia 30:869–873Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. Dorchy
    • 1
  • J. Duchateau
    • 2
  1. 1.Clinique de DiabétologieHôpital Universitaire des Enfants, Reine FabiolaBrusselsBelgium
  2. 2.Service d'ImmunologieHôpital Universitaire Saint-PierreBrusselsBelgium

Personalised recommendations