Abstract
We report the first case of Haemolytic-uraemic syndrome (HUS) associated with Streptococcus pneumoniae meningitis. This supports a common pathogenic mechanism in HUS following infections by neuraminidase-producing organisms and in pneumococcal meningitis. We recommend that HUS must be considered in cases of renal failure and/or anaemia associated with pneumococcal meningitis, and that bacterial meningitis be considered in all patients with HUS and central nervous system involvement.
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Abbreviations
- CSF:
-
cerebrospinal fluid
- HUS:
-
haemolyticuraemic syndrome
- RBC:
-
red blood cells
- T-ag:
-
Thomsen-Friedenreich antigen
References
Adelman RD, Halsted CC, Sheikholishlam BM (1980) Hemolyticuremic syndrome: associated conditions. J Pediatr 97:161–162
Alon U, Adler SP, Chan JCM (1984) Hemolytic-uremic syndrome associated with Streptococcus pneumoniae: report of a case and review of the literature. Am J Dis Child 138:496–499
Bale JF, Brasher C, Siegler RL (1980) CNS manifestations of the hemolytic-uremic syndrome. Relationship to metabolic alterations and prognosis. Am J Dis Child 134:869–872
Bird T, Stephenson J (1973) Acute haemolytic anaemia associated with polyagglutinability of red cells. J Clin Pathol 26:868–870
Gasser von C, Gautier E, Steck A, Siebenmann RE, Oechslin R (1955) Hämolytisch-urämische Syndrome: Bilaterale Nierenrindennekrosen bei akuten erworbenen hämolytischen Anämien. Schweiz Med Wochenschr 85:905–909
Klein PJ, Bulla M, Newman RA, Müller P, Uhlenbruck G, Schaefer HE, Krüger G, Fischer R (1977) The significance of the Thomsen-Friedenreich antigen in haemolyticuraemic syndrome. Lancet II:1024–1025
Seger R, Joller P, Baerlocher K (1980) Hemolytic-uremic syndrome associated with neurominidase-producing microorganisms: treatment by exchange transfusion. Helv Paediatr Acta 35:359–367
Vierbuchen M, Klein PJ (1983) Histochemical demonstration of neuraminidase effects in pneumococcal meningitis. Lab Invest 48:181–186
Von Eyben FE, Szpirt W (1985) Pneumococcal sepsis with hemolytic-uremic syndrome in the adult. Nephron 40:501–502
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Martinot, A., Hue, V., Leclere, F. et al. Haemolytic-uraemic syndrome associated with Streptococcus pneumoniae meningitis. Eur J Pediatr 148, 648–649 (1989). https://doi.org/10.1007/BF00441523
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DOI: https://doi.org/10.1007/BF00441523