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Tumour necrosis factor in neonatal listeriosis: a case report

  • Infectious Diseases
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Abstract

A newborn with fatal neonatal listeriosis developed septic shock, neutropenia, thrombocytopenia and profound hypoxaemia due to severe pulmonary hypertension. Tumour necrosis factor α, interleukin-1-β and interferon-γ serum concentrations were markedly elevated, suggesting the participation of these cytokines in the aetiopathogenesis of shock induced by Listeria monocytogenes in the neonate.

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Abbreviations

IFN-α:

interferon-α

IFN-γ:

interferon-γ

IL-1β:

interleukin-1β

MPA:

monocytosis producing agent

TNF-α:

tumour necrosis factor α

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Authors and Affiliations

  1. Department of Paediatrics and Genetics, Hôpital Cantonal Universitaire de Genève, CH-1211, Genève 4, Switzerland

    E. Girardin, M. Berner & S. Suter

  2. World Health Organization Immunology Research and Training Centre, Department of Pathology, University of Geneva, CMU, CH-1211, Genève 4, Switzerland

    G. E. Grau

  3. Immunology Division, Department of Internal Medicine, Hôpital Cantonal Universitaire de Genève, CH-1211, Genève 4, Switzerland

    J.-M. Dayer & P. Roux-Lombard

Authors
  1. E. Girardin
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  2. M. Berner
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  3. G. E. Grau
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  4. J.-M. Dayer
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  5. P. Roux-Lombard
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  6. S. Suter
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Girardin, E., Berner, M., Grau, G.E. et al. Tumour necrosis factor in neonatal listeriosis: a case report. Eur J Pediatr 148, 644–645 (1989). https://doi.org/10.1007/BF00441521

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  • DOI: https://doi.org/10.1007/BF00441521

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