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Precocious pseudopuberty associated with multiple ovarian follicular cysts and low plasma oestradiol concentrations


A 6 year 11 month old girl had pseudoprecocious puberty caused by multiple ovarian follicular cysts. In contrast to previously reported patients, oestrogen levels in blood and urine were not elevated though gonadotropins were suppressed. Despite the lack of measurable oestrogen elevation the child developed distinct oestrogenic effects. After removal of large bilateral ovarian cysts endocrine aberrations normalized and precocity regressed.

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E2 :



follicle-stimulating hormone


gonadotropin releasing hormone


human chorionic gonadotropin




luteinising hormone




sex hormone binding globulin


  1. Bidlingmaier F, Butenandt O, Knorr D (1977) Plasma gonadotropins and estrogens in girls with idiopathic precocious puberty. Pediatr Res 11:91–94

    Google Scholar 

  2. Chasalow FI, Granoff AB, Tse TF, Blethen SL (1986) Adrenal steroid secretion in girls with pseudoprecocious puberty due to autonomous ovarian cysts. J Clin Endocrinol Metab 63:828–834

    Google Scholar 

  3. de Sa DJ (1975) Follicular ovarian cysts in stillbirths and neonates. Arch Dis Child 50:45–50

    Google Scholar 

  4. Eberlein WR, Bongiovanni AM, Jones IT, Yakovac WC (1960) Ovarian tumors and cysts associated with sexual precocity. Report of 3 cases and review of the literature. J Pediatr 57:484–497

    Google Scholar 

  5. Liapi C, Evain-Brion D (1987) Diagnosis of ovarian follicular cysts from birth to puberty: a report of twenty cases. Acta Paediatr Scand 76:91–96

    Google Scholar 

  6. Monteleone JA, Monteleone PL, Danis RK (1973) Pseudoprecocious puberty associated with isolated follicular cyst of the ovary. J Pediatr Surg 8:949–950

    Google Scholar 

  7. Polhemus DW (1953) Ovarian maturation and cyst formation in children. Pediatrics 11:588–594

    Google Scholar 

  8. Scully RE, McNeely BU (1975) Case records of the Massachusetts general hospital. N Engl J Med 23:199–203

    Google Scholar 

  9. Sinnecker G, Lork S, Willig RP (1986) Gonadal and adrenal steroids and their binding globulins SHBG and CBG in patients treated with ethinylestradiol and testosterone oenanthate. Acta Endocrinol [Suppl 274] 111:18–20

    Google Scholar 

  10. Stanhope R, Adams J, Jacobs HS, Brook CGD (1985) Ovarian ultrasound assessment in normal children, idiopathic precocious puberty, and during low dose pulsatile gonadotrophin releasing hormone treatment of hypogonadotrophic hypogonadism. Arch Dis Child 60:116–119

    Google Scholar 

  11. Steiner MM, Hadawi SA (1964) Sexual precocity, association with follicular cysts of ovary. Am J Dis Child 108:28–36

    Google Scholar 

  12. Zipf WB, Kelch RP, Hopwood NJ, Spencer ML, Bacon GE (1979) Suppressed responsiveness to gonadotropin-releasing hormone in girls with unsustained isosexual precocity. J Pediatr 95:38–43

    Google Scholar 

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Sinnecker, G., Willig, R.P., Stahnke, N. et al. Precocious pseudopuberty associated with multiple ovarian follicular cysts and low plasma oestradiol concentrations. Eur J Pediatr 148, 600–602 (1989).

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Key words

  • Precocious pseudopuberty
  • Ovarian follicular cysts