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The effect of gonadotrophin releasing hormone analogue on height prognosis in growth hormone deficiency and normal puberty


We have treated seven pubertal children, five (three female, two male) with growth hormone deficiency and two (one female, one male) with constitutional short stature with intranasal (D-Serine6) gonadotrophin releasing hormone (GnRH) analogue (Buserelin) for a mean of 0.84 years (range, 0.5–1.3). Treatment was successful in arresting pubertal development but there was no improvement in final height prognosis.

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gonadotrophin releasing hormone


growth hormone


  1. Brauner R, Rappaport R (1985) Precocious puberty secondary to cranial irradiation for tumours distant from the hypothalamopituitary area. Hormone Res 22:78–82

    Google Scholar 

  2. Brook CGD (1982) Growth assessment in childhood and adolescence. Blackwell, Oxford

    Google Scholar 

  3. Eastman CJ, Lazarus L, Stuart MC, Casey JH (1971) The effect of puberty on growth hormone secretion in boys with short stature and delayed adolescence. Aust NZ J Med 1:154–159

    Google Scholar 

  4. Mansfield MJ, Beardsworth DE, Loughlin JS, Crawford JD, Bode HH, Rivier J, Vale W, Kushner DC, Crigler JF, Crowley WF (1983) Long-term treatment of central precocious puberty with a long-acting analogue of luteinising hormone-releasing hormone: effects on somatic growth and skeletal maturation. N Engl J Med 309:1286–1290

    Google Scholar 

  5. Prader A (1986) Pediatric endocrinology: past and future. In: Ranke MB, Bierich JR (eds) Pediatric endocrology, past and future. MD-Verlag, München, pp 13–21

    Google Scholar 

  6. Preece MA, Tanner JM (1977) Results of intermittent treatment of growth hormone deficiency with human growth hormone. J Clin Endocrinol Metab 45:169–170

    Google Scholar 

  7. Stanhope R, Adams J, Brook CGD (1985) The treatment of central precocious puberty using an intranasal LHRH analogue (Buserelin). Clin Endocrinol 22:795–806

    Google Scholar 

  8. Stanhope R, Pringle PJ, Brook CGD (1988) The mechanism of the adolescent growth spurt induced by low dose pulsatile GnRH treatment. Clin Endocrinol 28:83–91

    Google Scholar 

  9. Stanhope R, Pringle PJ, Brook CGD (1988) Growth, growth hormone and sex steroid secretion in girls with central precocious puberty treated with a gonadotrophin releasing hormone (GnRH) analogue. Acta Paediatr Scand (in press)

  10. Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healey M JR, Goldstein H (1983) Assessment of skeletal maturity and prediction of adult height (TW2 Method), 2nd edn. Academic Press, London

    Google Scholar 

  11. Werder EA, Illig R, Zachmann M, Torresani T, Prader A (1986) Treatment of precocious puberty in girls with intranasal LHRH agonist (Buserelin). Pediatr Res 20:1185

    Google Scholar 

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Stanhope, R., Brook, C.G.D. The effect of gonadotrophin releasing hormone analogue on height prognosis in growth hormone deficiency and normal puberty. Eur J Pediatr 148, 200–202 (1988).

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Key words

  • Puberty
  • Growth hormone deficiency
  • GnRH analogue
  • Height prognosis