European Journal of Pediatrics

, Volume 129, Issue 4, pp 267–272 | Cite as

HLA frequencies and haplotypes in children with idiopathic thrombocytopenic purpura (ITP)

  • K.-G. Evers
  • R. Thouet
  • W. Haase
  • J. Krüger


26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P=0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.

Key words

HLA antigens Idiopathic thrombocytopenic purpura 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • K.-G. Evers
    • 1
  • R. Thouet
    • 2
  • W. Haase
    • 2
  • J. Krüger
    • 3
  1. 1.Children's Hospital of the City of CologneCologneGermany
  2. 2.Institute of Numerical StatisticsCologneGermany
  3. 3.Department of Blood Transfusion of the University of CologneGermany

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