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Ataractics and strain differences in audiogenic seizures in mice

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Summary

  1. 1.

    Chlorpromazine was active in antagonizing audiogenic seizures of the DBA-1 strain and nonprotective against seizures in an inbred Swiss strain (O'Grady).

  2. 2.

    Reserpine was found to be slightly more active against seizures in the DBA strain than in the Swiss strain.

  3. 3.

    Meprobamate was approximately 18 times more active against seizures in the DBA strain than in the Swiss strain.

  4. 4.

    It is suggested that strain differences be considered when neurotropic agents are evaluated against audiogenic seizures in mice.

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Authors and Affiliations

  1. Stanford Research Institute Menlo Park, California

    N. Plotnikoff

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  1. N. Plotnikoff
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Plotnikoff, N. Ataractics and strain differences in audiogenic seizures in mice. Psychopharmacologia 1, 429–432 (1960). https://doi.org/10.1007/BF00441190

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  • DOI: https://doi.org/10.1007/BF00441190

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