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European Journal of Nuclear Medicine

, Volume 11, Issue 1, pp 36–42 | Cite as

Diffuse pulmonary uptake of 99mTc bone-imaging agents: Case report and survey

  • Jean-Luc Coolens
  • Paul Devos
  • Michel De Roo
Case Reports

Abstract

Over the past 5 years, we have encountered 6 cases of diffuse pulmonary uptake of 99m-Tc bone-scanning agents (incidence, 0.04%). To assess the significance of this phenomenon, we reviewed all of the cases reported since 1974 (Including our series, a total of 32 cases). Three groups can be discerned, the first consisting of 24 patients without radiological calcifications in the lungs and with hypercalcemia of different origins (mostly hyperparathyroidism). Of the eight autopsies performed in this group, seven revealed extensive calcifications in alveolar walls and lung vessels; the other autopsy showed no calcification at all and only bronchopneumonic lesions. The second group consists of 6 patients in chronic dialysis. The last group consists of 2 patients having diffuse pulmonary alveolar microlithiasis with extensive radiologic calcifications.

The mechanism of lung uptake of 99m-Tc bone-imaging agents is probably the same as that of bone uptake (chemisorption on hydroxyapatite crystals), although other uptake mechanisms have also been discussed.

Bone scintigraphy can be useful in the detection of early pulmonary calcifications, which have been associated with impaired pulmonary function and, due to their size, are generally not detected by X-ray.

Key words

99mTc bone-imaging agents extra skeletal uptake hypercalcemia 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Jean-Luc Coolens
    • 1
  • Paul Devos
    • 1
  • Michel De Roo
    • 1
  1. 1.Department of Nuclear MedicineUniversitaire Ziekenhuizen, K.U. LeuvenLeuvenBelgium

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