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Psychopharmacologia

, Volume 39, Issue 2, pp 151–162 | Cite as

Antagonism of morphine by long acting narcotic antagonists

  • Linda A. Dykstra
  • D. E. McMillan
  • L. S. Harris
Animal Studies

Abstract

The effects of three narcotic antagonists, diprenorphine, naltrexone, and naloxone were studied on the schedule-controlled behavior of pigeons. Naltrexone decreased the rate of responding under the FR and FI components of a multiple fixed-interval, fixed-ratio schedule. Naltrexone and diprenorphine were equipotent in blocking the rate-decreasing effects of morphine on schedule-controlled behavior when the antagonists were given immediately before morphine, and both were more potent morphine antagonists than naloxone. Higher doses of all 3 antagonists were required to block the effects of morphine as the time between the administration of the antagonist and morphine increased. Naltrexone provided a slightly better antagonism of morphine than diprenorphine when morphine was given 2 or 6 h after the antagonist and both antagonists had a longer duration of antagonist action than naloxone.

Key words

Morphine Naloxone Naltrexone Diprenorphine Antagonists Pigeon Multiple Schedule 

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Copyright information

© Springer-Verlag 1974

Authors and Affiliations

  • Linda A. Dykstra
    • 1
    • 2
  • D. E. McMillan
    • 2
  • L. S. Harris
    • 2
  1. 1.The Department of PsychologyUniversity of North CarolinaChapel Hill
  2. 2.Department of PharmacologyUniversity of North CarolinaUSA

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