Skip to main content
Log in

Behavioral specificity of chloralose-induced feeding in the rat

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

The latency of feeding in the satiated rat was markedly shortened after intraperitoneal injection of chloralose. Feeding generally began before the onset of drinking or sedation. The optimum dose to facilitate food intake appeared to be lower at night than by day. Chloralose has a primary appetite-inducing effect which is much more powerful than that of 2-deoxyglucose.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Baile, C. A., Mayer, J.: Hyperphagia in ruminants induced by a depressant. Science 151, 458–459 (1966)

    Google Scholar 

  • Blackburn, J. G.: Chloralose and food intake in rats. Physiol. Behav. 8, 791–792 (1972)

    Google Scholar 

  • Booth, D. A., Toates, F. M.: A physiological control theory of food intake: Mark 1. Bull. Psychon. Soc. 3, 442–444 (1974)

    Google Scholar 

  • Feldberg, W.: Anaesthesia and sleep-like conditions produced by injections into the cerebral ventricles of the cat. J. Physiol. (Lond.) 140, 20P-21P (1958)

    Google Scholar 

  • Jones, R. G., Booth, D. A.: Low-response for 2-deoxy-D-glucose-induced feeding and the involvement of peripheral factors. Submitted for publication (1974)

  • Le Magnen, J., Devos, M., Gaudillière, J.-P., Louis-Sylvestre, J., Tallon, S.: Role of lipostatic mechanism in regulation by feeding of energy balance in rats. J. comp. physiol. Psychol. 84, 1–23 (1973)

    Google Scholar 

  • Mabel, J. A., Baile, C. A., Mayer, J.: Hyperphagia induced by ventricular pressure and pentobarbitone in normal and hypothalamic obese rats. Lancet 1966 II, 472–473

    Google Scholar 

  • Miselis, R. R., Epstein, A. N.: Feeding induced by 2-deoxy-D-glucose injections into the lateral ventricle of the rat. Physiologist 13, 262 Abs (1970)

    Google Scholar 

  • Novin, D., VanderWeele, D. A., Rezek, M.: Infusion of 2-deoxy-D-glucose into the hepatic-portal system causes eating: evidence for peripheral glucose receptors. Science 181, 858–870 (1973)

    Google Scholar 

  • Seoane, J. R., Baile, C. A.: Feeding behavior in sheep as related to the hypnotic activities of barbiturates injected into the third ventricle. Pharmacol. Biochem. Behav. 1, 47–53 (1973)

    Google Scholar 

  • Stolerman, I. P.: Eating, drinking and spontaneous activity in rats after the administration of chlorpromazine. Neuropharmacology 9, 405–417 (1970)

    Google Scholar 

  • Strang, R. H. C., Bachelard, H. S.: Rats of cerebral glucose utilization in rats anaesthetized with phenobarbitone. J. Neurochem. 20, 987–996 (1973)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Booth, D.A., Nicholls, J. Behavioral specificity of chloralose-induced feeding in the rat. Psychopharmacologia 39, 145–150 (1974). https://doi.org/10.1007/BF00440844

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00440844

Key words

Navigation