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Untersuchungen über die Erythrocyten-Carboanhydrasen bei pathologischen Zuständen im Kindesalter

Erythrocyte carbonic anhydrases in various diseases of childhood

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Abstract

In a large number of pediatric patients total carboanhydrase activity and CA I-1-protein were measured in the erythrocyte. Children with cyanotic heart disease or pulmonary insufficiency had normal values. In a 2 1/2-year-old boy with chronic myeloid leukemia of the juvenile type the pattern corresponded to that of newborns. Children with mongolism had increased carboanhydrase levels. The amount of carboanhydrase within the single erythrocyte was reduced in irondeficiency anemia, but normal in β-thalassemia. Thyroid hormones selectively depress the synthesis of carboanhydrase I.

Zusammenfassung

Bei einem umfangreichen pädiatrischen Krankengut wurde die Carboanhydrase-Gesamtaktivität und das CA I-1-Protein in Erythrocyten gemessen. Kinder mit cyanotischen Vitien und pulmonaler Insuffizienz hatten normale Spiegel. Bei einem 2 1/2jährigen Patienten mit chronisch myeloischer Leukämie vom juvenilen Typ entsprachen die Verhältnisse denen eines Neugeborenen. Bei Mongolismus waren die CA-Konzentrationen erhöht. Bei Eisenmangel war der Gehalt des einzelnen Erythrocyten an Carboanhydrase herabgesetzt, bei β-Thalassämie normal. Schilddrüsenhormon unterdrückt selektiv die Synthese von Carboanhydrase I.

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  1. Universitäts-Kinderklinik Freiburg i. Br., Freiburg i. Br., Deutschland

    Helmut Wehinger

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  1. Helmut Wehinger
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Wehinger, H. Untersuchungen über die Erythrocyten-Carboanhydrasen bei pathologischen Zuständen im Kindesalter. Z. Kinder-Heilk. 114, 163–174 (1973). https://doi.org/10.1007/BF00440503

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