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Die cutan-allergische Reaktion auf 2,4-Dinitrochlorbenzol bei kindlichen Leukämien und soliden Tumoren

Allergic dermatitis following 2,4-dinitrochlorbenzol in childhood leukemia and solid tumors

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Abstract

The delayed type of hypersensitivity on the skin was studied after application of 2,4-dinitrochlorbenzol (DNCB) or tuberculin to 40 children who had either acute leukemia or solid tumors. Thirty-one patients were used as a control group. There was a significant difference in the results between the neoplasm group and the control group. It proved more difficult to sensitize the leukemia and tumor groups with DNCB. The negative reaction is thought to be caused primarily by irradiation therapy or by cytostatic agents. However, on remission of leukemia a higher amount of positive skin reactions was observed in spite of the cytostatic therapy. Children suffering from primary neurogenic tumors also showed significantly less positive reactions than those who had sarcoma. Therefore other factors must exist that influence the immunologic reaction. A plasma factor is to be discussed in this study.

Zusammenfassung

An 40 Kindern mit akuten Leukämien und soliden Tumoren sowie 31 Kontrollpatienten wurde das Verhalten der cutan-allergischen Spätreaktion auf 2,4-Dinitrochlorbenzol (DNCB) und Tuberkulin untersucht. Dabei ergaben sich bei Verlaufsbeobachtungen der Hautreaktionsstärke signifikante Unterschiede zwischen den beiden Malignomgruppen und dem Kontrollkollektiv. Kinder mit Leukosen oder soliden Tumoren ließen sich weit weniger gut gegen DNCB sensibilisieren als Patienten ohne neoplastische Erkrankungen. Der negative Testausfall wird zum großen Teil durch die cystostatische bzw. Strahlentherapie erklärt. Da jedoch Leukosepatienten in der Remissionsphase trotz cytostatischer Therapie häufiger positive Cutanreaktionen zeigten als im akuten Schub, ferner bei Kindern mit neurogenen Geschwülsten signifikant weniger positive Hautreaktionen auszulösen waren als bei Kindern mit sarkomatösen Tumoren, müssen noch andere Faktoren Einfluß auf die immunologische Reaktionslage nehmen. Ein Plasmafaktor wird diskutiert.

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Authors and Affiliations

  1. Universitäts-Kinderklinik Mainz, Mainz, Deutschland

    H. Schulte-Wissermann, M. Neidhardt & Y. Oda

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  1. H. Schulte-Wissermann
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Mit statistischer Beratung durch B. Friedel und W. Ehrenberg-Kieckebusch (Institut für Medizinische Statistik und Dokumentation der Universität Mainz, Direktor: Prof. Dr. S. Koller).

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Schulte-Wissermann, H., Neidhardt, M. & Oda, Y. Die cutan-allergische Reaktion auf 2,4-Dinitrochlorbenzol bei kindlichen Leukämien und soliden Tumoren. Z. Kinder-Heilk. 114, 143–154 (1973). https://doi.org/10.1007/BF00440501

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