Zeitschrift für Kinderheilkunde

, Volume 120, Issue 4, pp 293–298 | Cite as

Das Syndrom der „unangemessenen” Antidiuretinsekretion und die Ausscheidung von Aldosteron im Harn

  • J. Šolc
Article
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Zusammenfassung

Das Syndrom der „unangemessenen” Antidiuretinsekretion wurde auf Grund der von Bartter u. Schwartz aufgestellten Kriterien bei 3 Patienten, einem Neugeborenen mit Meningitis und zwei Kleinkindern unter cytostatischer Therapie, diagnostiziert und durch Einschränkung der Wasserzufuhr und parenterale Verabreichung hypertoner Kochsalzlösungen erfolgreich behandelt. Während der Entwicklungsphase und am Anfang der Behandlung entsprach die Aldosteronausscheidung der Altersnorm oder lag etwas darüber. In der Erholungsphase wurde eine herabgesetzte Aldosteronausscheidung festgestellt.

The syndrome of inappropriate secretion of antidiuretic hormone and the urinary excretion of aldosterone

Abstract

The syndrome of inappropriate ADH secretion was diagnosed on the basis of the cardinal features described by Bartter and Schwartz in 3 patients: one neonate with bacterial meningitis and two children respectively under Vincristin and Cyclophosphamide treatment. Treatment with fluid restriction and infusions of hypertonic saline led to a slow excretion of the water excess and to the restoration of both the body fluid volume and serum sodium concentration. The urinary excretion of aldosterone was found to be in the normal range or slightly increased during the development of the syndrome and at the beginning of the therapy. In the phase of recovery there was decresed urinary aldosterone.

Key words

Antidiuretic hormone Inappropriate secretion Aldosterone 

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Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • J. Šolc
    • 1
  1. 1.Kinderklinik der Medizinischen Fakultät der Karls-Universität in PlzeňČSSR

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