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Zeitschrift für Kinderheilkunde

, Volume 108, Issue 2, pp 149–155 | Cite as

Zur Phagocytose bei Rachitis

  • P. Kasal
  • J. Ströder
Article

Zusammenfassung

  1. 1.

    Die Phagocytose von Escherichia coli ist bei experimenteller Rachitis vermindert.

     
  2. 2.

    Es konnte nachgewiesen werden, daß für die herabgesetzte Phagocytose die thermostabile Serumopsonisationsaktivität verantwortlich ist.

     
  3. 3.

    Es wurde Abhängigkeit der Phagocytose vom Alter beobachtet.

     
  4. 4.

    Dagegen besteht bei experimenteller Rachitis normale bactericide Aktivität der Leukocyten.

     

Diese am Modell der diätetischen Rattenrachitis erhobenen Befunde stimmen prinzipiell überein mit den von uns früher mitgeteilten Tatsachen bei Vitamin D-Mangelrachitis des jungen Säuglings. Die Fakten können einer Diskussion der verminderten Infektresistenz bei Rachitis dienlich sein.

Phagocytosis in rickets

Abstract

  1. 1.

    It was shown, that in experimental rickets the phagocytosis of E. coli is reduced.

     
  2. 2.

    It was possible to demonstrate that the heat-stable serum opsonin activity is responsible for the reduction in phagocytosis.

     
  3. 3.

    It was observed that phagocytosis is age-dependent.

     
  4. 4.

    A normal bactericidal activity of leucocytes was, however, observed in experimental rickets.

     

These findings were obtained in rats with experimental dietetic rickets; they confirm in principle the findings which we reported earlier in young infants (rickets due to vitamin D deficiency). The data reported might be useful for the discussion of the reduced resistence to infections in rickets.

Key-Words

Phagocytosis Opzonization Bactericidies Infectious Resistence Rickets 

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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • P. Kasal
    • 1
  • J. Ströder
    • 1
  1. 1.Universitäts-Kinderklinik WürzburgWürzburgDeutschland

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