Abstract
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1.
It was shown, that in experimental rickets the phagocytosis of E. coli is reduced.
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2.
It was possible to demonstrate that the heat-stable serum opsonin activity is responsible for the reduction in phagocytosis.
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3.
It was observed that phagocytosis is age-dependent.
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4.
A normal bactericidal activity of leucocytes was, however, observed in experimental rickets.
These findings were obtained in rats with experimental dietetic rickets; they confirm in principle the findings which we reported earlier in young infants (rickets due to vitamin D deficiency). The data reported might be useful for the discussion of the reduced resistence to infections in rickets.
Zusammenfassung
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1.
Die Phagocytose von Escherichia coli ist bei experimenteller Rachitis vermindert.
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2.
Es konnte nachgewiesen werden, daß für die herabgesetzte Phagocytose die thermostabile Serumopsonisationsaktivität verantwortlich ist.
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3.
Es wurde Abhängigkeit der Phagocytose vom Alter beobachtet.
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4.
Dagegen besteht bei experimenteller Rachitis normale bactericide Aktivität der Leukocyten.
Diese am Modell der diätetischen Rattenrachitis erhobenen Befunde stimmen prinzipiell überein mit den von uns früher mitgeteilten Tatsachen bei Vitamin D-Mangelrachitis des jungen Säuglings. Die Fakten können einer Diskussion der verminderten Infektresistenz bei Rachitis dienlich sein.
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Herrn Professor Dr. Dr. h. c. Dr. h. c. Giovanni de Toni, Genua, zu seinem 75. Geburtstag in Verehrung gewidmet.
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Kasal, P., Ströder, J. Zur Phagocytose bei Rachitis. Z. Kinder-Heilk. 108, 149–155 (1970). https://doi.org/10.1007/BF00439881
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DOI: https://doi.org/10.1007/BF00439881