Virchows Archiv A

, Volume 389, Issue 2, pp 225–240 | Cite as

The concept of homology in quantitative organelle pathology

Application of symbolic logic to glycogenosis type I in the liver
  • U. N. Riede
  • G. William Moore
Original Articles


The process of quantification has led pathology into an objective and abstract direction to which it is unaccustomed. The introduction of the concept of homology in pathology by Doerr has proven to be very fruitful, since it has helped to clarify otherwise poorly understood relationships. As shown in the foregoing paper, the succes of the homology concept applies also to quantitative organelle pathology. Homologies have demonstrated relationships within the ergastoplasmic — mitochondrial — peroxisomal system which are apparent only with the help of symbolic logic. These homologies permit inferences, shown here with the example of glycogenosis type I, regarding the adaptive potential of the cell and the degree of cellular damage. In addition, these homologies, which are described in terms of formal logic, may serve as a model for human pathologic anatomy.

Key words

Homology Morphometry Symbolic logic Organelle pathology Glycogenosis 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Anderson JM, Johnstone HW jr (1962) Natural deduction. The logical basis of axiom systems. Wadsworth Publishing Co, Inc, Belmont, CaliforniaGoogle Scholar
  2. Bloch E (1975) Experimentum mundi. Suhrkamp, FrankfurtGoogle Scholar
  3. Carnap R (1958) Introduction to symbolic logic and its applications. Dover Publications, Inc, New YorkGoogle Scholar
  4. Cinti DL, Schenkman JB (1972) Hepatic organelle interaction. Mol Pharmacol 8:327–338Google Scholar
  5. Doerr W (1979) Homologiebegriff und pathologische Anatomie. Virchows Arch A Path Anat and Histol 383:5–29Google Scholar
  6. Herbener GH (1976) A morphometric study of age dependent changes in mitochondrial populations of mouse liver and heart. J Gerontology 31:8–12Google Scholar
  7. Hoppeler H, Luethi Pl, Claase H, Weibel ER, Howald H (1973) A morphometric analysis of the normal human sceletal muscle. Pflüger Arch ges Physiol 344:217–233Google Scholar
  8. Kolb-Bachofen V, Vogell W (1975) Mitochondrial proliferation in synchronized cells of Tetrahymena pyriformis. Exp Cell Res 94:95–108Google Scholar
  9. Legg P, Wood R (1969) New observations in microbodies. A cytochemical study on CPIB — treated rat liver. J Cell Biol 45:118–123Google Scholar
  10. McCluskey EJ jr (1956) Minimization of Boolean functions. Bell Systems Tech J 36:1417–1444Google Scholar
  11. Moore GW, Riede UN, Sandritter W (1977) Application of Quine's nullities to a quantitative organelle pathology. J Theor Biol 65:633–642Google Scholar
  12. Moore GW, Hutchins GM, Bulkley BH (1979) Certainty levels in the nullity method of symbolic logic: Application to the pathogenesis of congenital heart malformations. J Theor Biol 76:53–81Google Scholar
  13. Moore GW, Hutchins GM (1980) Effort and demand logic in medical decision making. Metamedicine (in press)Google Scholar
  14. Pette D, Brandau H (1962) Intracellular localization of glycolytic enzymes in cross-striated muscles of Locusta migratoria. Biochem Biophys Res Comm 9:367–378Google Scholar
  15. Quine WV (1948) Theory of deduction, Parts I–IV. Harvard Cooperative Society, Cambride, USA, p 54–81Google Scholar
  16. Quine WV (1950) Methods of logic. Henry Holt & Company, New YorkGoogle Scholar
  17. Quine WV (1952) The problem of simplifying truth functions. Am Math Monthly 59:521–531Google Scholar
  18. Quine WV (1955) A way to simplify truth functions. Am Math Monthly 62:627–631Google Scholar
  19. Riede UN, Seebass C, Rohr HP (1971) Ultrastructural morphometric study on rat hepatocytes after cycloheximide induced protein synthesis inhibition. Virchows Arch Abt B Zellpath 9:16–28Google Scholar
  20. Riede UN, Moore GW, Sandritter W (1980a) The application of symbolic logic to organelle pathology: Reaction patterns deduced from morphometric data. Path Res Pract 166:165–187Google Scholar
  21. Riede UN, Moore GW, Sandritter W (1980b) Structure and function of peroxisomes and their role in disease processes. In: Trump BF and Arstila AV (eds.) Pathobiology of cell membranes, vol. II. Academic Press, New York, p 173–220Google Scholar
  22. Riede UN, Spycher MA, Gitzelmann R (1980c) Glycogenosis type I (Glucose-6-phosphatase deficiency): I. Ultrastructural morphometric analysis of juvenile liver cells. Path Res Pract 167:136–150Google Scholar
  23. Riede UN, Moore GW, Saudritter W (1980d) Symbolic logic as a new method in quantitative organelle pathology. Exp. Mol Pathol (zum Druck angenommen)Google Scholar
  24. Rohr HP, Wirz A, Henning LC, Riede UN, Bianchi L (1971a) Morphometric analysis of the rat liver cell in the perinatal period. Lab Invest 24:128–139Google Scholar
  25. Rohr HP, Riede UN (1973) Experimental metabolic disorders in the subcellular reaction pattern. Curr Top Pathol 58:1–48Google Scholar
  26. Rohr HP, Lüthy J, Oberholzer M, Gysin C, Bianchi L (1976) Stereology of liver biopsies from healthy volunteers. Virchows Arch A Path Anat and Histol 371:251–263Google Scholar
  27. Schole J, Harisch G, Sallmann HP (1978) Belastung, Ernährung und Resistenz. J Anim Nutrit 9:7–79Google Scholar
  28. Snyder DP (1971) Modal logic and its applications. Van Nostrand Reinhold Company, New York London, p 1–57Google Scholar
  29. Spycher M, Gitzelmann R (1971) Glycogenosis type I (Glucose-6-phosphatase-deficiency): Ultrastructural alterations of hepatocytes in a tumor bearing liver. Virchows Arch Abt B Zellpath 8:133–142Google Scholar
  30. Trump BF, Arstila AU (eds) (1975) Pathobiology of cell membranes, Bd I, Academic Press New York San Francisco LondonGoogle Scholar
  31. Weibel ER (1969) Stereological principles for morphometry in electronmicroscopic cytology. Int Rev Cytol 26:235–256Google Scholar
  32. Wilson JW, Leduc EH (1963) Mitochondrial changes in the liver of essential fetty acid-deficient mice. J Cell Biol 16:281–296Google Scholar

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • U. N. Riede
    • 1
    • 2
  • G. William Moore
    • 1
    • 2
  1. 1.Department of Pathology, Ludwig Aschoff InstituteUniversity of FreiburgFreiburg i.Br.Germany
  2. 2.Department of PathologyThe Johns Hopkins Medical InstitutionsBaltimoreUSA

Personalised recommendations