Psychopharmacology

, Volume 97, Issue 3, pp 402–403 | Cite as

Double-blind evaluation of the effect of acute amantadine on cocaine craving

  • Frank H. Gawin
  • Charles Morgan
  • Thomas R. Kosten
  • Herbert D. Kleber
Original Investigations

Abstract

Single doses of amantadine hydrochloride and placebo were administered in a double-blind cross-over design on separate days to ten actively craving cocaine abusers in treatment. Pharmacological treatment did influence cocaine craving, but amantadine was less effective than placebo.

Key words

Cocaine Amantadine Withdrawal Stimulant abuse Dependence 

References

  1. Butzer JF, Silber DE, Sahs AL (1975) Amantadine in Parkinson's disease. Neurology 25:603–606.Google Scholar
  2. Gawin FH (1988) Chronic neuropharmacology of cocaine: progress in pharmacotherapy. J Clin Psycho [Suppl 2] 49:11–16.Google Scholar
  3. Gawin FH, Ellinwood EH (1988) Cocaine and other stimulants: Actions, abuse and treatment. New Engl J Med 318:1173–1183.Google Scholar
  4. Gawin FH, Byck R, Kleber HD (1986) Desipramine augmentation of cocaine abstinence: initial results. Presented at the 15th meeting of the Colliegium Internationale Neuropharmacologicum. San Juan, Puerto Rico. December 15, 1986 (Proceedings in: Clin Neuropharmacol [Suppl 4] 9:202–204)Google Scholar
  5. Gianutsos G, Chute S, Dunn JP (1985) Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine. Eur J Pharmacol 110:357–361.Google Scholar
  6. Murray TJ (1985) Amantadine therapy for fatigue in multiple sclerosis. Can J Neurol Sci 12(3):251–254.Google Scholar
  7. Rizzo M, Biandrate P, Tognoni G (1973) Amantadine in depression: relationship between behavioral effects and plasma levels. Eur J Clin Pharmacol 5:226–228.Google Scholar
  8. Tennant F (1988) Treatment of cocaine abusers with multi-stage pharmacotherapy. In: Harris LS (ed) Proc Comm on Problems of Drug Dependence. 1987 (in press)Google Scholar
  9. Tennant F, Sagherian A (1987) Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from cocaine dependence. Arch Int Med 14:109–112.Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Frank H. Gawin
    • 1
  • Charles Morgan
    • 1
  • Thomas R. Kosten
    • 1
  • Herbert D. Kleber
    • 1
  1. 1.Department of PsychiatryYale University School of MedicineNew HavenUSA

Personalised recommendations