Abstract
Twelve social drinkers were given a 0.7 g/kg dose of alcohol mixed with a distinctively flavoured drink in each of five sessions, and the same drink with no alcohol in a further three sessions. All sessions were conducted in the same room. The alcohol increased heart rate, but with repeated administration change was slower to begin. In the first placebo session the change in heart rate was a decrease below baseline level, particularly in the early part of the session. Repeated administration of the placebo resulted in a diminution of this alcohol-opposite conditioned response.
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References
Childress AR, McClellan AT, O'Brien CD (1986) Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal, and reductions in both through extinction. Br J Addict 81:655–660.
Newlin DB (1986) Conditioned compensatory response to alcohol placebo in humans. Psychopharmacology 88:247–251.
O'Brien CP (1986) Experimental analysis of conditioning factors in human narcotic addiction. Pharmacol Rev 27:533–543.
Siegel S (1978) A Pavlovian conditioning analysis of morphine tolerance. In: Krasnegor NA (ed) Behavioural tolerance: research and treatment implications. Nat Inst Drug Abuse Res Monogr, vol 18. US Government Printing Office, Washington DC, pp 27–53.
Siegel S (1985) Classical conditioning, drug tolerance and drug dependence. In: White L, Tursky, B, Schwartz B (eds) Placebo: clinical phenomena and new insights. Guilford Press, New York, pp 207–246.
Staiger PK, White JM (1988) Conditioned alcohol-like and alcohol-opposite responses in humans. Psychopharmacology 95:87–91.
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Macfarlane, S.J., White, J.M. Acquisition and extinction of an alcohol-opposite conditioned response in humans. Psychopharmacology 97, 355–357 (1989). https://doi.org/10.1007/BF00439450
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DOI: https://doi.org/10.1007/BF00439450