Archives of Orthopaedic and Trauma Surgery

, Volume 109, Issue 2, pp 72–74 | Cite as

Antibiotic prophylaxis in lower-extremity amputations due to ischemia

A prospective, randomized trial of Cephalothin versus Methicillin
  • S. Thomsen
  • B.W. Jakobsen
  • J. O. Wethelund
  • J. Dalsgaard
  • H. N. Gregersen
  • U. Lucht
Original Articles


The efficiency of prophylactic antibiotic therapy in amputation surgery was studied in a prospective, randomized trial of a first-generation cephalosporin (cephalothin) compared with a narrow-spectrum betalactam stable penicillin (methicillin). Eighty-eight patients received cephalothin 2 g x 4 on the day of operation, while 86 patients received methicillin 1 g x 4. The patients were followed up for 21 days. Infected wounds occurred in 14.8% of the patients in the cephalothin group, compared with 14% in the methicillin group. The frequency of deep infections was 10.2% versus 4.7% (P = 0.1611). The reamputation frequency was 18.2% in the cephalothin group compared with 12.8% in the methicillin group; the frequency of below-knee reamputation was 18.4% versus 7.7% (P = 0.1469). No clostridial infections were found. The study did not demonstrate any significant difference between cephalothin and methicillin in the prophylaxis for lower-extremity amputations, although the latter drug tended to be the best choice.


Ischemia Penicillin Randomized Trial Antibiotic Therapy Good Choice 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • S. Thomsen
    • 2
  • B.W. Jakobsen
    • 1
  • J. O. Wethelund
    • 1
  • J. Dalsgaard
    • 2
  • H. N. Gregersen
    • 2
  • U. Lucht
    • 1
  1. 1.Department of Orthopedic Surgery EAarhus Municipal HospitalAarhusDenmark
  2. 2.Department of Orthopedic Surgery OAalborg HospitalAalborgDenmark

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