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Psychopharmacology

, Volume 81, Issue 1, pp 37–41 | Cite as

Effect of low-dose bromocriptine in treatment of psychosis: The dopamine autoreceptor-stimulation strategy

  • H. Y. Meltzer
  • T. Kolakowska
  • A. Robertson
  • B. J. Tricou
Original Investigations

Abstract

Bromocriptine (0.5–6.0 mg/day) was administered to seven unmedicated chronic schizophrenic and two schizoaffective patients. Transient slight improvement was noted in four patients and marked improvement in one other. Clinical improvement was associated with nausea and drowsiness. These doses of bromocriptine stimulated serum growth hormone and inhibited serum prolactin levels in some subjects. These results suggest that bromocriptine may stimulate dopamine autoreceptors and, through this mechanism, attenuate symptoms in a small proportion of psychiatric patients.

Key words

Bromocriptine Dopamine Schizophrenia Autoreceptor Prolactin Growth hormone 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • H. Y. Meltzer
    • 1
    • 2
  • T. Kolakowska
    • 1
  • A. Robertson
    • 1
    • 2
  • B. J. Tricou
    • 1
    • 2
  1. 1.Department of PsychiatryUniversity of Chicago, Pritzker School of MedicineChicagoUSA
  2. 2.Illinois State Psychiatric InstituteChicago

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