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Purified moniliformin does not affect the force or rate of contraction of isolated guinea pig atria

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Abstract

Chronic exposure to moniliformin results in the development of myocardial hypertrophy and degeneration. The cause of this hypertrophy is unknown. However, moniliformin-induced hypoxia or altered function of cardiac pyruvate dehydrogenase, rather than direct cardiostimulation have been proposed as potential mechanisms. Isolated guinea pig atria were used in a cumulative concentration-response model to evaluate the direct effect of moniliformin on the rate and force of atrial contraction. Moniliformin did not affect the rate or force of atrial contraction. These results are consistent with the hypothesis that moniliformin does not have a cardiostimulatory effect. Therefore cardiac stimulation, e.g. stimulation of beta-adrenergic receptors, is unlikely to be the cause of the myocardial hypertrophy observed hi poultry chronically intoxicated with moniliformin.

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Author notes

  1. Rachel Y. Reams

    Present address: New Bolton Center, University of Pennsylvania, 382 West Street Road, 19348-1692, Kennett Square, PA, USA

Authors and Affiliations

  1. The Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, Indiana

    Rachel Y. Reams, H. Leon Thacker & Daniel D. Harrington

  2. Department of Veterinary Pathobiology, Purdue University, West Lafayette, Indiana

    Rachel Y. Reams, H. Leon Thacker, Daniel D. Harrington & Meliton N. Novilla

  3. Eli Lilly and Company, Greenfield, Indiana

    Meliton N. Novilla & Billie Wilson

Authors
  1. Rachel Y. Reams
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  2. H. Leon Thacker
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  3. Daniel D. Harrington
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  4. Meliton N. Novilla
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  5. Billie Wilson
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Reams, R.Y., Thacker, H.L., Harrington, D.D. et al. Purified moniliformin does not affect the force or rate of contraction of isolated guinea pig atria. Mycopathologia 133, 115–118 (1996). https://doi.org/10.1007/BF00439122

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  • DOI: https://doi.org/10.1007/BF00439122

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