Abstract
A longitudinal study of red cell enzyme activity in newborn infants of low birth weight has been conducted over the first 2 months of life. The enzymes investigated are acetylcholinesterase (EC 3.1.3.7), an integral part of the red cell membrane and subnormal in AB0 hemolytic disease of the newborn; and glucose-6-phosphate dehydrogenase (EC 1.1.1.49), an intracellularly-located, sex-linked enzyme, implicated in neonatal jaundice and of significance in drug-induced hemolytic anemias. Acetylcholinesterase activity, which is lower in normal full-term newborn infants and in low birth weight infants than in adults, was further diminisched during the initial weeks of life of the infants of low birth weight and the higher levels of activity, characteristic of adult red cells, had not appeared by 2 months of age. By contrast, red cell glucose-6-phosphate dehydrogenase activity, which is higher in full-term newborn infants and in infants of low birth weight than in adults, did not diminish as a function of age and the lower adult levels were not discernible by 2 months of life.
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Butenandt, O.: Glutathion, Glutathionperoxydase, Glutathionreduktase, Glucose-6-Phosphatdehydrogenase, Lactat-dehydrogenase und Katalase in Erythrocyten von Neugeborenen, Säuglingen und Kinder und ihre Beziehung zur Heinzkörperbildung. Z. Kinderheilk. 111, 149–161 (1971)
Gross, R. T., Hurwitz R. E.: The pentose phosphate pathway in human erythrocytes. Relationship between the age of the subject and enzyme activity. Pediatrics 22, 453–459 (1958)
Herz, F., Kaplan, E.: A review: Human erythrocyte acetylcholinesterase. Pediat. Res. 7, 204–214 (1973)
Herz, F., Kaplan, E., Scheye, E. S.: Erythrocyte acetylcholinesterase and glucose-6-phosphate dehydrogenase in newborn infants of low birth weight. Clin. chim. Acta 46, 147–152 (1973)
Herz, F., Kaplan, E., Stevenson, J. H. Jr.: Acetylcholinesterase inactivation in enzymetreated erythrocytes. Nature (Lond.) 200, 901–902 (1963)
Kaplan, E., Herz, F., Hsu, K. S.: Erythrocyte acetylcholinesterase activity in AB0 hemolytic disease of the newborn. Pediatrics 33, 205–211 (1964)
Kaplan, E., Tildon, J. T.: Changes in red cell enzyme activity in relation to red cell survival in infancy. Pediatrics 32, 371–375 (1963)
Lu, T. C.: A study of serum bilirubin levels and erythrocyte glucose-6-phosphate dehydrogenase activities in Chinese premature infants. Acta paediat. Sin. 5, 1–12 (1964)
Marks, P. A., Johnson, A. B.: Relationship between the age of human erythrocytes and their osmotic resistance: A basis for separating young and old erythrocytes. J. clin. Invest. 37, 1542–1548 (1958)
Oski, F. A., Kamazawa, M.: Metabolism of the erythrocytes of the newborn infant. Seminars Hematol. 12, 209–221 (1975)
Stave, U., Hintz, H.: Über die Erythrocyten der Frühgeborenen. Hämatologische und enzymologische Studien im ersten Lebensjahr. Z. Kinderheilk. 86, 184–197 (1961)
Stewart, A. G., Birkbeck, J. A.: The activities of lactate dehydrogenase, transaminase, and glucose-6-phosphate dehydrogenase in the erythrocytes and plasma of newborn infants. J. Pediat. 61, 395–404 (1962)
Volpato, S., Baggio, P., Sacchetto, A.: A propos de quelques activités enzymatiques érythrocytaire de la période néo-natale, dans les conditions normales et pathologiques. Ann. Pediat. 38, 627–631 (1962)
WHO Scientific Group: Treatment of haemoglobinopathies and allied disorders. WHO Tech. Rep. Ser. 509, 19 (1972)
Zinkham, W. D.: An in vitro abnormality of glutathione metabolism in erythrocytes from normal newborns: Mechanism and clinical significance. Pediatrics 23, 18–32 (1959)
Zipursky, A.: The erythrocytes of the newborn infant. Seminars Hematol. 2, 167–203 (1965)
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Herz, F., Kaplan, E. & Scheye, E.S. A longitudinal study of red cell enzymes in infants of low birth weight. Z. Kinder-Heilk. 120, 217–221 (1975). https://doi.org/10.1007/BF00439011
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DOI: https://doi.org/10.1007/BF00439011